The circumstances in which the monoclonal antibody is more useful as an anti-cancer agent as compared to the polyclonal antibody is to be explained. Concept introduction: A single antigen has many antigenic determinants (epitopes) to which specific immunoglobulins bind. In the antisera, a mixture of antibodies of different specificity for all the epitopes is present. These immunoglobulins are synthesized by the B cells. There is only one kind of antibody produced by each plasma B cell and its clones to neutralize the foreign antigens. One immunoglobulin can also show varied specificity to only one epitope of the antigen.

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Chapter 30, Problem 74P

Interpretation Introduction

Interpretation: The circumstances in which the monoclonal antibody is more useful as an anti-cancer agent as compared to the polyclonal antibody is to be explained.

Concept introduction:

A single antigen has many antigenic determinants (epitopes) to which specific immunoglobulins bind. In the antisera, a mixture of antibodies of different specificity for all the epitopes is present. These immunoglobulins are synthesized by the B cells. There is only one kind of antibody produced by each plasma B cell and its clones to neutralize the foreign antigens. One immunoglobulin can also show varied specificity to only one epitope of the antigen.

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