Chapter 30, Problem 30.73P

Interpretation Introduction

Interpretation:

The relationship between B₁₂ and depression should be explained.

Concept Introduction:

The structure of B₁₂ contains a corrin ring like the porphyrin ring present in heme. The central metal ion is cobalt which is coordinated to corrin ring in four of the six coordination sites. The fifth coordination site is coordinated with a dimethyl benzimidazole group. The sixth coordination site is reactive center which is variable, this can be cyano group, hydroxyl group, or methyl group or 5’-deoxyadenosyl group resulting four forms of B₁₂.