Concept explainers
a.
To determine: The effective crossing program that can be used to obtain the a/a; b/b; c/c pure line.
Introduction. The genetic material is all the living organism is the DNA (deoxyribonucleic acid). All the eukaryotes as well the prokaryotes have defined set of DNA sequence, which is inherited from one generation to another and codes for all the characters of the organism.
b.
To determine: The
Introduction. The DNA (deoxyribose
c.
To determine: The alternative method of obtaining desired genotype.
Introduction. The process of
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Introduction To Genetic Analysis
- Pedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. If Sarah carries the mutant cancer allele and Adam carries the mutant heart disease allele, what is the chance that they would have a child who is free of both diseases? Are these good odds?arrow_forwardPedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you want to know the results of the cancer, heart disease, and TSD tests if you were Sarah and Adam? Is it their responsibility as potential parents to gather this type of information before they decide to have a child?arrow_forwardPedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you decide to have a child if the test results said that you carry the mutation for breast and ovarian cancer? The heart disease mutation? The TSD mutation? The heart disease and the mutant alleles?arrow_forward
- A couple enters your genetic counseling clinic for some family planning advice. The woman’s father was color blind, but her own vision is normal. The man has no family history of color blindness. Neither the man nor woman have any known history of hemophilia, but their first child (a boy) has hemophilia. They ask you to calculate the chance that their nextchild will be affected by one or both conditions. You remember from your genetics training that these are both X-linked recessive conditions and that they are closely linked: in fact, their genetic loci are separated by only 10cM! During the interview with this couple, you draw the following pedigree to represent their information. Given what you know, determine for this couple what chance they have of each of the following (in the table).arrow_forwardAfter a cross between two corn plants, the F₁ plants all had a dwarf mutant phenotype. The F2 consisted of 1,207 dwarf plants and 401 tall plants. Identify the phenotypes and genotypes of the two parents. O d/d (dwarf), D+/d (tall) D/D (dwarf), d+/d+ (tall) D/D (dwarf), D+/D+ (tall) d/d (dwarf), d+/d+ (tall)arrow_forward1)se; 12 cM 2)h; 12 cM 3)g; 8 cM 4)se; 8 cMarrow_forward
- Mendel obtained his initial pea plant varieties from local breeders who were developing new varieties that might be useful or interesting. To generate these new varieties, breeders formed hybrids between existing varieties of different phenotypic characteristics by cross pollination, using techniques they doubtless taught to Mendel. After producing a hybrid, they allowed several generations of self-pollination, as happens naturally if the flowers are not disturbed. a. How many generations would it take for a breeder to have produced new pure-breeding varieties using this approach? b. What is the probability that an individual in each of these generations (F2, F3, and F10) would be homozygous for one or the other allele of this gene?arrow_forwardMendel obtained his initial pea plant varieties from local breeders who were developing new varieties that might be useful or interesting. To generate these new varieties, breeders formed hybrids between existing varieties of different phenotypic characteristics by cross pollination, using techniques they doubtless taught to Mendel. After producing a hybrid, they allowed several generations of self-pollination, as happens naturally if the flowers are not disturbed. a. How many generations would it take for a breeder to have produced new pure-breeding varieties using this approach? i. First, consider just one heterozygous gene in the F1 hybrid. What is the probability that an individual of the F2 generation would be heterozygous for that gene? ii. What is the probability that an individual in the F3 generation would be heterozygous for this gene? iii. What is the probability that an individual in the F10 generation would be heterozygous for this gene? iv. What is the…arrow_forwardPart A: If the two genes are 30 mu apart and the plant is (AB/ab), what proportion of gametes from a single plant will be AB? Enter your answer as a decimal to three places (for example: 0.120). Part B: If the two genes are 30 mu apart and the plant is (AB/ab), what proportion of gametes from a single plant will be Ab? Part C: If the two genes are 30 mu apart and the plant is (AB/ab), what proportion of gametes from a single plant will be aB? Part D: If the two genes are 30 mu apart and the plant is (AB/ab), what proportion of gametes from a signal plant will be ab?arrow_forward
- Each generation is represented by a Roman Numeral and each individual by a number. Based on the pedigree above, there are 2 generations. I-1 is the male parent and l-2 is the female parent. Generation Il are their children, with Il-1 as the eldest (daughter), Il-2 the middle child (son) and II-3 another daughter as the youngest. An arrow that points to any individual in the pedigree chart identifies the individual as a proband, an individual affected with a disorder (II-3 in the pedigree above) who is the first subject in a study (as of a genetic character in a family lineage) (Merriam-Webster.com). The proband can be specified in the problem. Answer the following using the spaces provided. 1. This pedigree tracks the inheritance of freckles, an autosomal dominant trait, for 3 generations. Determine the genotypes of all individual in the chart. 1-1 III-1 II-2 Il-1 1-2 Il-2 Il-3 Il-4 III-3 III-4 Il-5 III-5 III-6 If III-6 marries someone without freckles, is it possible for them to have…arrow_forwardIn letter B: If the map distance equals the number of recombinant/total of offspring, wouldn't it be 24/806 x 100? Wouldn't we add both recombinants? Can you explain letter C? I don't grasp that concept well. And since I'm using my question already, would you be able to answer D. Thank you!arrow_forwardIn the previous topic, you learned that Gregor Mendel used Pisum sativum to conceptualize the governing laws of Genetics. In this activity, we will recall how Gregor Mendel utilized the idea of classical breeding to come up with desirable traits. Supposed you have two individual peas. One of the peas is a pure breed with round green seeds while the other has heterozygous round yellow seeds. Supposed a farmer wants to have pure breed peas that have green wrinkled seeds. How are you going to come up with these traits using the two peas that you have? (Note: If the F1 does not include a pure breed green wrinkled seed, you will use the F1 peas for next generation breeding and so on until you have the desired traits. Pure breed means homozygous alleles.) Show the Punnett squares for the cross. You will come up with two or more squares based on how many generations you made.arrow_forward
- Concepts of BiologyBiologyISBN:9781938168116Author:Samantha Fowler, Rebecca Roush, James WisePublisher:OpenStax CollegeHuman Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning