FUND. OF ANATOMY & PHYSIOLOGY F16 PKG
10th Edition
ISBN: 9781323431122
Author: Martini
Publisher: PEARSON C
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Textbook Question
Chapter 29, Problem 23RQ
Distinguish between the following paired terms: (a) genotype and
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 29 Solutions
FUND. OF ANATOMY & PHYSIOLOGY F16 PKG
Ch. 29 - Define differentiation.Ch. 29 - What event marks the onset of development?Ch. 29 - Define inheritance.Ch. 29 - Prob. 4CPCh. 29 - Prob. 5CPCh. 29 - Define gestation.Ch. 29 - Characterize the key features of each trimester.Ch. 29 - What is the developmental fate of the inner cell...Ch. 29 - Improper development of which of the...Ch. 29 - Prob. 11CP
Ch. 29 - Prob. 10CPCh. 29 - Prob. 12CPCh. 29 - Prob. 14CPCh. 29 - Prob. 13CPCh. 29 - Prob. 15CPCh. 29 - Prob. 16CPCh. 29 - Prob. 17CPCh. 29 - Prob. 18CPCh. 29 - Prob. 19CPCh. 29 - What is the difference between colostrum and...Ch. 29 - Prob. 21CPCh. 29 - Describe the relationship between genotype and...Ch. 29 - Prob. 23CPCh. 29 - Prob. 24CPCh. 29 - Prob. 25CPCh. 29 - The chorionic villi (a) form the umbilical cord,...Ch. 29 - Identify the two extra-embryonic membranes and the...Ch. 29 - The hormone that is the basis for a pregnancy test...Ch. 29 - Recessive X-linked traits (a) are passed from...Ch. 29 - Prob. 5RQCh. 29 - Prob. 6RQCh. 29 - Prob. 7RQCh. 29 - If an allele must be present on both the maternal...Ch. 29 - Prob. 9RQCh. 29 - (a) What are the four extra-embryonic membranes?...Ch. 29 - Prob. 11RQCh. 29 - List the factors involved in initialing labor...Ch. 29 - Identify the three life stages that occur between...Ch. 29 - What hormonal events are responsible for puberty?...Ch. 29 - A normally pigmented woman whose father was an...Ch. 29 - Prob. 16RQCh. 29 - Prob. 17RQCh. 29 - After implantation, how does the developing embryo...Ch. 29 - Name the primary placental hormones and their...Ch. 29 - Prob. 20RQCh. 29 - During true labor, what physiological mechanisms...Ch. 29 - What physiological adjustments must an infant make...Ch. 29 - Distinguish between the following paired terms:...Ch. 29 - Indicate the type of inheritance involved in each...Ch. 29 - Hemophilia A, a condition in which blood does not...Ch. 29 - Joe and Jane desperately want to have children,...Ch. 29 - Prob. 27RQCh. 29 - Prob. 28RQCh. 29 - Prob. 1CCCh. 29 - Are Hans and Willem monozygotic twins or dizygotic...
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