BIOL:CONCEPT+INVEST.ETEXT
BIOL:CONCEPT+INVEST.ETEXT
5th Edition
ISBN: 9781264154173
Author: Hoefnagels
Publisher: MCG
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Chapter 29, Problem 1WIO
Summary Introduction

To analyze:

The common findings in the patients who receive the bone marrow transplant.

Introduction:

Inside bones, there is a fatty, squishy substance called bone marrow. Hematopoietic stem cells are immature cells found in this bone marrow. When necessary, these stem cells can divide to produce all different kinds of new blood cells. In order to replenish the stem cell population if these cells are killed or injured, a bone marrow transplant may be required.

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Imagine that you are a clinical geneticist. Your colleague is an oncologist who wants your help explaining the basics of genetics to their patient, who will be undergoing genetic testing in the coming weeks for possible acute myeloid leukemia (AML) induced by the radiation she had several years ago for breast cancer. Write a 1,050- to 1,225-word memo to your colleague. Include the following in your memo: An explanation of the molecular structure of DNA and RNA, highlighting both similarities and differences  A description of the processes of transcription and translation An explanation of the differences between leading and lagging strands and how the DNA is replicated in each strand Reponses to the following common questions patients might ask about this type of genetic testing and genetic disorder: Does AML run in families? What genes are tested for?
Respond to the following in a minimum of 175 words: What are some potential consequences that could result if the processes of replication, transcription, and translation don’t function correctly? Provide an example of how you might explain these consequences in terms that patients might understand.
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