Concept explainers
(a)
Interpretation:
Calculate the number of ATP molecules produced in skeletal muscle from each molecule of glucose undergoing glycolysis alone.
Concept Introduction:
The following process occurs during complete
- Glycolysis
- Link reaction
- Kreb’s cycle
- Electron transport system
(b)
Interpretation:
Calculate the number of ATP molecules produced in skeletal muscle from each molecule of pyruvate converting to acetyl CoA.
Concept Introduction:
The link reaction between glycolysis and citric acid cycle is conversion of pyruvate to acetyl CoA.
(c)
Interpretation:
Calculate the number of ATP molecules produced in skeletal muscle during complete oxidation of glucose to carbon dioxide and water.
Concept Introduction:
The following process occurs during complete metabolic pathway of glucose.
- Glycolysis
- Link reaction
- Kreb’s cycle
- Electron transport system
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Introduction to General, Organic and Biochemistry
- Write a generalized chemical equation, containing acronyms, for the hydrolysis of ATP to ADP.arrow_forwardWhich of the following substances can be considered as metabolic intermediates? Water ATP Pyruvic acid Glucosearrow_forwardBelow is the overall net equation for the complete oxidation of pyruvate. Calculate the number of ATP molecules that can be produced from the complete oxidation of 6 molecules of pyruvate. Pyruvate + 4NAD+ + FAD + GDP + Pi + 2H₂O → 3CO2 + 4NADH + 4H+ + FADH2 + GTP (Given: The oxidation of one NADH yields 2.5 ATP; the oxidation of one FADH2 yields 1.5 ATP; and one GDP yields 1 ATP.) O 75 ATP O 60 ATP O 12.5 ATP O 32 ATParrow_forward
- What key metabolic intermediate is formed from the catabolism of all three major classes of foods: carbohydrates, lipids, and proteins?arrow_forwardTrypanosomes living in the bloodstream obtain all their free energy from glycolysis. They take up glucose from the host’s blood and excrete pyruvate as a waste product. In this part of their life cycle, trypanosomes do not carry out any oxidative phosphorylation, but they do use another oxygen-dependent pathway, which is absent in mammals, to oxidize NADH. Would this pathway be necessary if the trypanosome excreted lactate rather than pyruvate? Explain.arrow_forwardAnaerobic glycolysis (i.e., lactic acid fermentation) produces pyruvate that is then converted to lactate through the activity of lactate dehydrogenase. The conversion of pyruvate to lactate would seem to be an unnecessary step, since this process does not result in any further release of energy. Explain the necessity for the production of lactate as the endpoint for anaerobic glycolysis.arrow_forward
- Determine the number of ATP molecules that can be formed from the complete oxidation of 10 molecules of acetyl CoA. The overall net equation for the complete oxidation of acetyl CoA is provided below. Acetyl CoA + 3NAD+ + FAD + GDP + Pi + 2H₂O → 2CO2 + HS-CoA + 3NADH + 3H+ + FADH2 + GTP (Given: The oxidation of one NADH yields 2.5 ATP; the oxidation of one FADH2 yields 1.5 ATP; and one GDP yields 1 ATP.) O 10 ATP O 7,5 ATP O 100 ATP O 75 ATParrow_forwardHow many electron carrier molecules (both NADH and FADH₂) are made per glucose put in to glycolysis? How many electron carrier molecules (both NADH and FADH₂) are made per pyruvate put in to the Krebs Cycle? How many electron carrier molecules (both NADH and FADH₂) are made by the Krebs Cycle per glucose consumed by the organism? How many electron carrier molecules in total (both NADH and FADH₂) have been made from a single glucose after both glycolysis and the Krebs Cycle? How many electrons are being carried from glucose at this point (Hint: 2 per molecule)?arrow_forwardShort answer questions. You must show work indicating production or consumption of molecules such as ATP or NADH in the various pathways involved in these questions. Consider that a molecule of alanine can be converted to pyruvate by an oxidation reaction that produces one NADH. If the liver is to make a molecule of glucose from alanine, how many molecules of alanine are required? How many ATP equivalents are required?arrow_forward
- The following reaction constitutes the first step in the citric acid cycle. List all the reactants in this reaction? H₂O COO™ C=O || CH3-C-CoA Acetyl COA CH₂ COO™ Oxaloacetate HS-COA Citrate synthase O Citrate and HS-COA COO™ I CH₂ HO-C-COO CH₂ COO™ Citrate Water, Acetyl CoA, and HS-CoA O Oxaloacetate and Acetyl CoA Oxaloacetate, Acetyl CoA, and HS-COA O Oxaloacetate, Acetyl CoA, and Waterarrow_forwardDuring the overall process of glycolysis, in which of the following occurs for each glucose molecule processed. net loss of two ATP molecules net loss of four ATP molecules net gain of two ATP molecules net gain of four ATP moleculesarrow_forwardPlease do both.arrow_forward
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