Biology 2e
2nd Edition
ISBN: 9781947172517
Author: Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher: OpenStax
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Chapter 27, Problem 16RQ
Until recent discoveries suggested otherwise, animals existing before the Cambrian period were believed to be:
- small and ocean-dwelling
- small and nonmotile
- small and soft-bodied
- small and radially symmetrical or asymmetrical
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 27 Solutions
Biology 2e
Ch. 27 - Figure 27.5 If a Hox 13 gene in a mouse was...Ch. 27 - Figure 27.6 Which of the following statements is...Ch. 27 - Figure 27.9 Which of the following statements...Ch. 27 - Which of the following is not a feature common to...Ch. 27 - During embryonic development, unique cell layers...Ch. 27 - Which of the following phenotypes would most...Ch. 27 - Which of the following organisms is most likely to...Ch. 27 - Which of the following is not possible? radially...Ch. 27 - An animal whose development is marked by radial...Ch. 27 - Consulting the modern phylogenetic tree of...
Ch. 27 - Which of the following is thought to be the most...Ch. 27 - As with the emergence of the Acoelomorpha phylum,...Ch. 27 - Which of the following periods is the earliest...Ch. 27 - What type of data is primarily used to determine...Ch. 27 - The time between 542-488 million years ago marks...Ch. 27 - Until recent discoveries suggested otherwise,...Ch. 27 - Plant life first appeared on land during which of...Ch. 27 - Approximately how many mass extinction events...Ch. 27 - Why might the evolution of specialized tissues be...Ch. 27 - Describe and give examples of how humans display...Ch. 27 - How have Hox genes contributed to the diversity of...Ch. 27 - Using the following terms, explain what...Ch. 27 - Explain some of the advantages brought about...Ch. 27 - Describe at least two major changes to the animal...Ch. 27 - How is it that morphological data alone might lead...Ch. 27 - Briefly describe at least two theories that...Ch. 27 - How is it that most if not all, of the extant...
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