Organic Chemistry
Organic Chemistry
7th Edition
ISBN: 9780321803221
Author: Paula Y. Bruice
Publisher: Prentice Hall
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Chapter 26.4, Problem 7P

The 2',3’-cyclic phosphodiester that is formed (Figure 26.7) when RNA is cleaved, forms a mixture of nucleotide 2' - and 3'-phosphates when it reacts with water. Propose a mechanism for this reaction.

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Consider the reactants below. Answer the following questions about the reaction mechanism and products. HO Cl
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The electrons flow from the electron-rich atoms of the nucleophile to the electrons poor atoms of the alkyl halide. Identify the electron rich in the nucleophile. Enter the element symbol only, do not include any changes.

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