Chapter 26.16, Problem 24P

Interpretation Introduction

Interpretation:

The steps in the preparation of $\text{Phe-Gly}$ by the Merrifield method are to be outlined.

Concept Introduction:

In Merrifield method peptide coupling and de-protection is carried out on a solid polymer which has $-{\text{CH}}_{\text{2}}\text{Cl}$ groups at the surface.

Nucleophilic substitution of the chlorine in the $-{\text{CH}}_{\text{2}}\text{Cl}$ group by the carboxylate of an $\text{N-Boc-protected}$ C-terminal amino acid anchors it to the polymer, protecting the C-terminus.