Chapter 26.15, Problem 22P

Interpretation Introduction

Interpretation:

The steps involved in the synthesis of $\text{Ala-Leu}$ from alanine and leucine using benzyloxycarbonyl and benzyl ester protecting groups and DCCI-promoted bond formation are to be shown.

Concept Introduction:

Direct reaction between two amino acids results in a mixture of four dipeptides.

Synthesis of a particular dipeptide as the sole product requires protecting the amine group of the amino acid that forms the N-terminus and the carboxyl group of the amino acid that forms the C-terminus of the peptide.