Chapter 26, Problem 11CT

Summary Introduction

Case summary:

If the mutations occur in aquaporin-3 and aquaporin-4 in the cells of the collecting duct that resulted in a reduced number of these aquaporins. It affects the urine volume and concentration.

Adequate information:

The anti-diuretic hormone (ADH) helps in decreasing the urine volume. The posterior pituitary gland secretes it. Its secretion is stimulated by the osmoreceptor cells present in the plasma. They produce their response during an increased ion concentration of the blood.

To determine:

The effect produces on urine volume and concentration after mutation in aquaporin. Also, ADH is an effective treatment that is to be determined.

Given information:

The mutation in the aquaporin will reduce the number of these water channels on the distal tubule and collecting duct cells. It affects the concentration and volume of urine.