Anatomy & Physiology (6th Edition)
Anatomy & Physiology (6th Edition)
6th Edition
ISBN: 9780134156415
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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Chapter 25.5, Problem 15CYU
Summary Introduction

To review:

The two mechanisms, by which the tubule and collecting duct cells generate new HCO3-.

Introduction:

Variations in diet or metabolism or disease can result in acid-base imbalances in the body. The kidneys regulate acid-base balance by adjusting the amount of bicarbonate (HCO3-) in the blood.

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The Na+-glucose transporters SGLT2 and SGLT1 are located at different levels of the kidney proximal tubule to minimize spillover of the glucose into the urine (See diagram attached) a) Consider the Na+-glucose coupling ratios for SGLT2 and SGLT1. Why would localization of SGLT2 in the early proximal tubule and SGLT1 in the late proximal tubule be advantageous? b) The Michaelis constant (Km) for the SGLT2 and SGLT1 transporters are 2 mM and 0.5 mM, respectively. Is SGLT2 or SGLT1 the higher affinity Na+-glucose transporter? d) Dapagliflozin is an SGLT1 inhibitor and commonly prescribed to treat type 2 diabetes. Why would this be of benefit to a diabetes patient?

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Anatomy & Physiology (6th Edition)

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