Anatomy & Physiology (6th Edition)
Anatomy & Physiology (6th Edition)
6th Edition
ISBN: 9780134156415
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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Chapter 25.5, Problem 16CYU
Summary Introduction

To review:

The intracellular enzyme and theblood concentration of the ion that increases when the urine in renal tubule cells and the parietal cells in the stomach are acidified.

Introduction:

The acidic medium in the stomach helps in the activation of digestive enzymes, which helps in the breakdown of food. Excess of acid level in the body is regulated by acidifying the urine and excreting it out of the body.

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Carbonic anhydrase is strongly inhibited by the drug acetazolamide, which is used as a diuretic (i.e., to increase the production of urine) and to lower excessively high pressure in the eye (due to accumulation of intraocular fluid) in glaucoma. Carbonic anhydrase plays an important role in these and other secretory processes because it participates in regulatingthe pH and bicarbonate content of several body fluids. The experimental curve of initial reaction velocity (as percentage of Vmax ) versus [S] for the carbonic anhydrase reaction is illustrated below (upper curve). When the experiment is repeated in the presence of acetazolamide, the lower curve is obtained. From an inspection of the curves and your knowledge of the kinetic properties of competitive and mixed enzyme inhibitors, determinethe nature of the inhibition by acetazolamide. Explain your reasoning.
ch 25 act 9 please answer the questions in the picture attached
Suppose a patient has chronic metabolic acidosis, perhaps from type Il diabetes. Suppose a clinic is treating the acidosis by administering bicarbonate in the blood. If the kidney's removal of bicarbonate were inconsistent, what is something simple the clinic could do to check if the dosage of bicarbonate is appropriate?

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Anatomy & Physiology (6th Edition)

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