Fundamentals of General, Organic, and Biological Chemistry (8th Edition)
Fundamentals of General, Organic, and Biological Chemistry (8th Edition)
8th Edition
ISBN: 9780134015187
Author: John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher: PEARSON
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Chapter 25, Problem 25.22AP
Interpretation Introduction

Interpretation:

Structure of products formed from the transamination of pyruvate and oxaloacetate has to be determined.

Concept introduction:

  • Transamination of amino acid is the reaction in which amino group is converted to keto acid and formation of a new amino acid takes place.
  • The reaction is the interchange of amino group from given amino acid with the keto group from α-ketoglutarate. During transamination reaction α-ketoglutarate gives glutamate as the product. The product from the amino acid is the keto group.
  • Oxidative deamination is the removal of NH4+ bonded to αcarbon and replacing them by a C=O gives the desired α-ketoacid.

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Explain the chemical change that occurs in converting kynurenine (a product of tryptophan degradation) to kynurenate, a reaction in which α-ketoglutarate is transformed to glutamate.
In what condition and why is pyruvate converted to lactate?
a-Keto acids other than a-ketoglutarate can accept the amino group from pyridoxamine in enzyme-catalyzed transamination reactions. What amino acids are formed when the following a-keto acids accept the amino group?O OO O Opyruvate oxaloacetate

Chapter 25 Solutions

Fundamentals of General, Organic, and Biological Chemistry (8th Edition)

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