Brock Biology of Microorganisms (15th Edition)
15th Edition
ISBN: 9780134261928
Author: Michael T. Madigan, Kelly S. Bender, Daniel H. Buckley, W. Matthew Sattley, David A. Stahl
Publisher: PEARSON
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Chapter 24.10, Problem 1CR
Summary Introduction
Human microbiome consists of all the microorganisms present in the entire human body. Every organ present in the human body consists of its own microbiota and any disturbance in them is associated with the cause of disease. For example, the loss of beneficial microflora present in the intestine due to intake of antibiotics is related to the cause of Clostridium difficile infection in intestines. The main symptoms of the infection are recurrent diarrhea, inflammation in colon, and abdominal cramps.
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19. On the diagram below
a. Label the three pictures as: DNA; polypeptide; or RNA.
b. Label the arrows as: translation or transcription/RNA processing.
c. Add the following details to the diagram.
Promoter region
TATA box
Transcription start site
Transcription terminator
Intron (A,B,C,D)
Exons (1,2,3,4,5)
Splice sites
5' cap
5' UTR (untranslated region)
3' poly A tail
3' UTR (untranslated region)
Translational start (AUG)
Translational stop (UGA, UAG, or UAA)
N and C ends of polypeptide
0000
Match the letter labels in the figure below to the terms. Some letter
labels are not used.
MNNNNNNIN
M
C
B
A
M
D
F
E
H
K
G
8
The diagram below illustrates a quorum sensing pathway from Staphylococcus aureus. Please answer the following questions.
1. Autoinduction is part of the quorum sensing system. Which promoter (P2 or P3) is critical for autoinduction?
2)This staphylococcus aureus grows on human wounds, causing severe infections. You would like to start a clinical trial to treat these wound infections. Please describe:
a) What molecule do you recommend for the trial. Why?
b) Your trial requires that Staphylococcus aureus be isolated from the wound and submitted to genome sequencing before admittance. Why? What are you testing for?
3) If a mutation arises where the Promoter P3 is constitutively active, how would that influence sensitivity to AIP? Please explain your rationale.
4) This pathway is sensitive to bacterial cell density. Describe two separate mutation that would render the pathway active independent of cell density. Briefly explain your rationale.
Mutation 1
Mutation 2
Chapter 24 Solutions
Brock Biology of Microorganisms (15th Edition)
Ch. 24.1 - Which major body sites are heavily colonized by...Ch. 24.1 - What methods have been used to assess the human...Ch. 24.1 - Prob. 3MQCh. 24.1 - Prob. 1CRCh. 24.2 - How does the general metabolism of microorganisms...Ch. 24.2 - What is an enterotype?Ch. 24.2 - QHow do microbial diversity and abundance vary...Ch. 24.3 - Prob. 1MQCh. 24.3 - Identify the major microbes that predominate in...Ch. 24.3 - Prob. 3MQ
Ch. 24.3 - Prob. 1CRCh. 24.4 - Prob. 1MQCh. 24.4 - Prob. 2MQCh. 24.4 - Prob. 1CRCh. 24.5 - Prob. 1MQCh. 24.5 - Prob. 2MQCh. 24.5 - Prob. 1CRCh. 24.6 - Prob. 1MQCh. 24.6 - Prob. 2MQCh. 24.6 - Prob. 3MQCh. 24.6 - What are the major anatomical differences between...Ch. 24.7 - Prob. 1MQCh. 24.7 - Prob. 2MQCh. 24.7 - What factor(s) are most important in the...Ch. 24.7 - Prob. 1CRCh. 24.8 - Prob. 1MQCh. 24.8 - Prob. 2MQCh. 24.8 - Prob. 3MQCh. 24.8 - Prob. 1CRCh. 24.9 - What observations indicate that dental carries are...Ch. 24.9 - Prob. 2MQCh. 24.9 - What are some clinical advantages of a...Ch. 24.9 - Why might a therapy based on colonization of the...Ch. 24.10 - Prob. 1MQCh. 24.10 - Prob. 2MQCh. 24.10 - Prob. 1CRCh. 24.11 - Prob. 1MQCh. 24.11 - Prob. 2MQCh. 24.11 - What is the mechanism by which C. scindens...Ch. 24 - Prob. 1AQ
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