To estimate: The half-life of phosphodiester bond in DNA in years. Concept introduction: The linkage that bounds the sugars molecules (in both DNA and RNA) present on the closest nucleotides is called as the phosphodiester bond. This usually covalently links between 3′ carbon atom of one sugar molecule and 5′ carbon atom of adjacent sugar molecule present in deoxyribose molecule (DNA) and ribose molecule (RNA). Half-life or half-time of a substance or a matter is the time taken for the decomposition of half of the substance that was present initially. The strong covalent bond of phosphodiester bond makes them difficult to decompose and more half-life period.

Question

Want to see the full answer?

Answer 1

Question

Chapter 24, Problem 6E

Summary Introduction

To estimate: The half-life of phosphodiester bond in DNA in years.

Concept introduction: The linkage that bounds the sugars molecules (in both DNA and RNA) present on the closest nucleotides is called as the phosphodiester bond. This usually covalently links between 3′ carbon atom of one sugar molecule and 5′ carbon atom of adjacent sugar molecule present in deoxyribose molecule (DNA) and ribose molecule (RNA). Half-life or half-time of a substance or a matter is the time taken for the decomposition of half of the substance that was present initially. The strong covalent bond of phosphodiester bond makes them difficult to decompose and more half-life period.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Students have asked these similar questions

In 1956, E. P. Kennedy and S. B. Weiss published their study of membrane lipid phosphatidylcholine (lecithin) synthesis in rat liver. Their hypothesis was that phosphocholine joined with some cellular component to yield lecithin. In an earlier experiment, incubating 32 P-labeled phosphocholine at physiological temperature (37 °C) with broken cells from rat liver yielded labeled lecithin. This became their assay for the enzymes involved in lecithin synthesis. Determine the optimal pH for this enzyme and characterize the enzyme activity at different pH values. -O-P-O-CH2-CH₁₂-N(CH3)3 Phosphocholine H₂C-O-C-R HC-O-C-R2 + + + Cell fraction + ? HC-O-P-O-CH₁₂-CH₂-N(CH), O Phosphatidylcholine The researchers then centrifuged the broken cell preparation to separate the membranes from the soluble proteins. They tested three preparations: whole extract, membranes, and soluble proteins. Table 1 summarizes the results. Table 1: Cell fraction requirement for incorporation of 32p-phosphocholine into…

Researchers isolated an unknown substance, X, from rabbit muscle. They determined its structure from the following observations and experiments. (a) Qualitative analysis showed that X was composed entirely of C, H, and O. A weighed sample of X was completely oxidized and the H2O and CO2 produced were measured. This quantitative analysis revealed that X contained 40.00% C, 6.71% H, and 53.29% O by weight. (b) The molecular mass of X, as determined by mass spectrometry, was 90.00 atomic mass units (u). (c) Infrared spectroscopy showed that X contained one double bond. (d) X dissolved readily in water, and the solution demonstrated optical activity when tested in a polarimeter. (e) The aqueous solution of X is acidic. What is the empirical formula of X?

Show work. don't give Ai generated solution....give correct solution