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Concept explainers
To determine: The number of histone variants in the human cell.
Concept introduction: Histones are the proteins that wind and pack DNA to form a compact structure called nucleosomes. There are five different types of histone proteins, namelyH1, H2A, H2B, H3, and H4. Apart from the major canonical histone types, there are many variants that provide the different functions to them.
To explain: How the histone variants differ from each other.
Concept introduction: Histones are the proteins that wind and pack DNA to form a compact structure called nucleosomes. There are five different types of histone proteins, namelyH1, H2A, H2B, H3, and H4. Apart from the major canonical histone types, there are many variants that provide the different functions to them.
To determine: The way how the histone variant CENP-A relates to the chromosomal structure.
Concept introduction: Histones are the proteins that wind and pack DNA to form a compact structure called nucleosomes. There are five different types of histone proteins, namelyH1, H2A, H2B, H3, and H4. Apart from the major canonical histone types, there are many variants that provide the different functions to them.
To determine: The histone variant that is associated with X-chromosome inactivation.
Concept introduction: Histones are the proteins that wind and pack DNA to form a compact structure called nucleosomes. There are five different types of histone proteins, namelyH1, H2A, H2B, H3, and H4. Apart from the major canonical histone types, there are many variants that provide the different functions to them.
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Chapter 24 Solutions
Fundamentals of Biochemistry: Life at the Molecular Level
- An enzyme lowers the activation energy, (AG) of a reaction from 50.0 kcal/mol to 40.0 kcal/mol. Calulate the catalytic power at 310K. (R-1.987x10 kcal/mol)arrow_forwardDraw a typical axodendritic synapse, including a specific neurotransmitter of your choice, its associated postsynaptic receptors (indicating whether they are ionotropic or metabotropic), and any associated reuptake transporters or degradation enzymes. Please include a description of what specific steps would occur as an action potential reaches the axonal terminal.arrow_forwardGive a full arrow pushing mechanism of the spontaneous redox reaction between NAD+/NADH and oxaloacetate/malate. Please include diagram drawing of the mechanism! (Thank You!)arrow_forward
- 18. Which one of the compounds below is the major organic product obtained from the following series of reactions? 1. BH3 2. H2O2, NaOH H₂CrO4 CH2N2 oro ororos A B C D Earrow_forward17. Which one of the compounds below is the major organic product obtained from the following series of reactions? CI benzyl alcohol OH PBr3 Mg 1. CO2 SOCl2 ? ether 2. H+, H₂O CI Cl HO OH CI Cl A B C D Earrow_forward14. What is the IUPAC name of this compound? A) 6-hydroxy-4-oxohexanenitrile B) 5-cyano-3-oxo-1-pentanol C) 5-cyano-1-hydroxy-3-pentanone D) 1-cyano-5-hydroxy-3-pentanone E) 5-hydroxy-3-oxopentanenitrile HO. CNarrow_forward
- 13. What is the IUPAC name of this compound? A) 5-hydroxy-3,3-dimethylpentanoic acid B) 3,3-dimethylpentanoic acid C) 3,3-dimethyl-1-oxo-1,5-pentanediol D) 1,5-dihydroxy-3,3-dimethylpentanal E) 4-hydroxy-2,2-dimethylbutanoic acid HO OHarrow_forwardHelp me understand how carbon disulfide leads to toxicity in the brain, using terms like distal axonopathy, neurofilaments, covalent cross-linking, adducts, etc.,...please intuitively explain what is happening and where and the effects of it. For example, I know that CS2 reacts with amide and sulfhydryl groups on proteins, but what proteins exactly and where are they located?arrow_forwardWhat is the standard free energy change (in kJ/mole) of the spontaneous reaction between Oxygen and NADH to form H2O2 and NAD+?arrow_forward
- Redox Chemistry: Give standard free energy changes expected for the following reactions:-Succinate -> fumarate (using FAD/FADH2)-Oxaloacetate -> Malate (using NAD/NADH)-NADH --> NAD+ (using FMN/FMNH2)-CoQ --> CoQH2 (using Cytochrome C)arrow_forwardGive examples of balanced redox reactions that match the following:-Catabolic-Anabolic-Oxidative-Reductivearrow_forwardIf there are 20uM of a GLUT2 transporter on the surface of a cell, each able to move 8 per second, and 50mM glucose outside of the cell, what is the flux into the cell in mM/sec?arrow_forward
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