MICROBIOLOGY: EVOLV.SCI.-W/ACCESS>CI<
4th Edition
ISBN: 9780393622805
Author: SLONCZEWSKI
Publisher: Norton custom
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Chapter 24, Problem 4RQ
Summary Introduction
To review:
The characteristics that distinguish the IgA antibody from the IgG antibody.
Introduction:
Antibodies are the Y shaped large molecules that combine with the antigen for neutralizing pathogenic effects. Antibodies are also termed as immunoglobulins generated from plasma cells that are utilized by the immune system. These generated antibodies associated with antigen, counteract and destroy the antigenic effects while protecting other healthy tissues.
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Biopharmaceutics and Pharmacokinetics:Two-Compartment Model Instant Absorption Questions
SHOW ALL WORK, including equation used, variables used and each step to your solution, report your regression lines and axes names (with units if appropriate) :Calculate a-q
a) B1,
b) B2,
c) hybrid rate constant (1)
d) hybrid rate constant (2)
e) t1/2,dist
f) t1/2,elim
g) k10
h) k12
i) k21
j) initial concentration (C0)
k) central compartment volume (V1)
l) steady-state volume (Vss)
m) clearance (CL) AUC (0→10 min) using trapezoidal rule
n) AUC (20→30 min) using trapezoidal rule
o) AUCtail (AUC360→∞)
p) total AUC (using short cut method)
q) volume from AUC (VAUC)
Glitazones reduce insulin resistance by binding to a transcription factor in adipocytes, thereby reducing thesecretion of fatty acids. Glitazones are taken orally (in pill form). Using pharmacokinetic modeling, deriveequations to describe how the concentration of glitazones varies in the plasma as a function of time. Yourequations should be of the form: dCglitazone /dt = something, or dMglitazone /dt = something. Your model shouldinclude three compartments: the gut, the plasma, and the fatty tissues. Make sure to include a diagram thatillustrates your thinking, state all assumptions, and define your variables. Do not solve the equations.
Chapter 24 Solutions
MICROBIOLOGY: EVOLV.SCI.-W/ACCESS>CI<
Ch. 24.1 - Prob. 1TQCh. 24.1 - Prob. 2TQCh. 24.1 - Prob. 3TQCh. 24.2 - Prob. 1TQCh. 24.2 - Prob. 2TQCh. 24.2 - Prob. 3TQCh. 24.2 - Prob. 4TQCh. 24.2 - Prob. 5TQCh. 24.3 - Prob. 1TQCh. 24.3 - Prob. 2TQ
Ch. 24.3 - Prob. 3TQCh. 24.4 - Prob. 1TQCh. 24.4 - Prob. 2TQCh. 24.5 - Prob. 1TQCh. 24.5 - Prob. 2TQCh. 24.6 - Prob. 1TQCh. 24.6 - Prob. 2TQCh. 24 - Prob. 1RQCh. 24 - Prob. 2RQCh. 24 - Prob. 3RQCh. 24 - Prob. 4RQCh. 24 - Prob. 5RQCh. 24 - Prob. 6RQCh. 24 - Prob. 7RQCh. 24 - Prob. 8RQCh. 24 - Prob. 9RQCh. 24 - Prob. 10RQCh. 24 - Prob. 11RQCh. 24 - Prob. 12RQCh. 24 - Prob. 13RQCh. 24 - Prob. 14RQCh. 24 - Prob. 15RQCh. 24 - Prob. 16RQCh. 24 - Prob. 17RQCh. 24 - Prob. 18RQCh. 24 - Prob. 19RQCh. 24 - Prob. 20RQCh. 24 - Prob. 1TQCh. 24 - Prob. 2TQCh. 24 - Prob. 3TQCh. 24 - Prob. 4TQCh. 24 - Prob. 5TQ
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