CONNECT ACCESS CARD FOR ANATOMY AND PHYSIOLOGY
8th Edition
ISBN: 9781259880193
Author: SALADIN
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Chapter 23.5, Problem 15BYGO
Summary Introduction
Introduction:
Excreting the
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The Na+-glucose transporters SGLT2 and SGLT1 are located at different levels of the kidney proximal tubule to minimize spillover of the glucose into the urine (See diagram attached)
a) Consider the Na+-glucose coupling ratios for SGLT2 and SGLT1. Why would localization of SGLT2 in the early proximal tubule and SGLT1 in the late proximal tubule be advantageous?
b) The Michaelis constant (Km) for the SGLT2 and SGLT1 transporters are 2 mM and 0.5 mM, respectively. Is SGLT2 or SGLT1 the higher affinity Na+-glucose transporter?
d) Dapagliflozin is an SGLT1 inhibitor and commonly prescribed to treat type 2 diabetes. Why would this be of benefit to a diabetes patient?
What is the countercurrent multiplier system?
Electrophoretic flow and electroosmotic flow (EOF) plays an important role in capillary electrophoresis (CE) for ions movement.
Explain the differences between electrophoretic flow and EOF.
b) Suggest two different approaches (other than reducing the voltage) to reduce the electroosmotic flow.
c) Three water soluble vitamins: niacinamide (a neutral compound), riboflavin (a neutral compound) and thiamine (a cation) were separated by micellar electrokinetic capillary chromatography (MEKC) in 15 mM borate buffer (pH 8) with 50 mM sodium dodecyl sulfate. The migration times were niacinamide (7.5 min), riboflavin (12.8 min) and thiamine (13.9 min)
Explain why these vitamins were separated using MEKC.
Explain why niacinamide and riboflavin (both are neutral compounds) have different migration times.
(i) With the aid of a diagram, differentiate flow profile of electroosmotic flow (EOF) and laminar flow.
(ii) Discuss the effect of both flows in term of peak resolution.
Chapter 23 Solutions
CONNECT ACCESS CARD FOR ANATOMY AND PHYSIOLOGY
Ch. 23.1 - State at least four functions of the kidneys other...Ch. 23.1 - Prob. 2BYGOCh. 23.1 - Prob. 3BYGOCh. 23.1 - Prob. 1AYLOCh. 23.1 - Prob. 2AYLOCh. 23.1 - Prob. 3AYLOCh. 23.1 - Blood urea nitrogen, azotemia, and uremia, and the...Ch. 23.1 - Prob. 5AYLOCh. 23.2 - Prob. 4BYGOCh. 23.2 - Prob. 5BYGO
Ch. 23.2 - Prob. 6BYGOCh. 23.2 - Prob. 1AYLOCh. 23.2 - Prob. 2AYLOCh. 23.2 - Three layers of tissue that surround and...Ch. 23.2 - Prob. 4AYLOCh. 23.2 - Prob. 5AYLOCh. 23.2 - Prob. 6AYLOCh. 23.2 - Prob. 7AYLOCh. 23.2 - Prob. 8AYLOCh. 23.2 - Prob. 9AYLOCh. 23.2 - Prob. 10AYLOCh. 23.2 - Prob. 11AYLOCh. 23.2 - Prob. 12AYLOCh. 23.3 - Prob. 7BYGOCh. 23.3 - Prob. 8BYGOCh. 23.3 - Prob. 9BYGOCh. 23.3 - Prob. 10BYGOCh. 23.3 - Prob. 1AYLOCh. 23.3 - Prob. 2AYLOCh. 23.3 - Prob. 3AYLOCh. 23.3 - Prob. 4AYLOCh. 23.3 - Prob. 5AYLOCh. 23.3 - Prob. 6AYLOCh. 23.3 - How the myogenic mechanism of renal autoregulation...Ch. 23.3 - Structure and function of the juxtaglomerular...Ch. 23.3 - Prob. 9AYLOCh. 23.3 - Prob. 10AYLOCh. 23.3 - Prob. 11AYLOCh. 23.4 - Prob. 1AYLOCh. 23.4 - Prob. 2AYLOCh. 23.4 - Prob. 3AYLOCh. 23.4 - Prob. 4AYLOCh. 23.4 - Prob. 5AYLOCh. 23.4 - Prob. 6AYLOCh. 23.4 - Prob. 7AYLOCh. 23.4 - The reabsorption of water, Cl-, and glucose by the...Ch. 23.4 - Prob. 12BYGOCh. 23.4 - Prob. 13BYGOCh. 23.5 - Prob. 1AYLOCh. 23.5 - Prob. 2AYLOCh. 23.5 - Prob. 3AYLOCh. 23.5 - Function of the countercurrent multiplier and how...Ch. 23.5 - Prob. 5AYLOCh. 23.5 - Prob. 14BYGOCh. 23.5 - Prob. 15BYGOCh. 23.5 - Prob. 16BYGOCh. 23.6 - Prob. 1AYLOCh. 23.6 - Prob. 2AYLOCh. 23.6 - Prob. 3AYLOCh. 23.6 - Prob. 4AYLOCh. 23.6 - Prob. 5AYLOCh. 23.6 - Prob. 6AYLOCh. 23.6 - Prob. 7AYLOCh. 23.6 - Prob. 8AYLOCh. 23.6 - Prob. 17BYGOCh. 23.6 - Prob. 18BYGOCh. 23.6 - Prob. 19BYGOCh. 23.6 - Prob. 20BYGOCh. 23.7 - Prob. 21BYGOCh. 23.7 - Prob. 22BYGOCh. 23.7 - Prob. 23BYGOCh. 23.7 - The route and mechanism of urine transport from...Ch. 23.7 - Prob. 2AYLOCh. 23.7 - Prob. 3AYLOCh. 23.7 - Anatomy of the male urethra, its three segments,...Ch. 23.7 - The mechanism of the spinal micturition reflex and...Ch. 23.7 - Prob. 6AYLOCh. 23 - Beavers have relatively little need to conserve...Ch. 23 - Prob. 10TYRCh. 23 - Prob. 11TYRCh. 23 - _______ is the ability of a nephron to adjust its...Ch. 23 - The two ureters and the urethra form the...Ch. 23 - The _______ is a group of epithelial cells of the...Ch. 23 - To enter the capsular space, filtrate must pass...Ch. 23 - Glycosuria occurs if the rate of glomerular...Ch. 23 - Prob. 17TYRCh. 23 - Prob. 18TYRCh. 23 - Prob. 19TYRCh. 23 - Prob. 20TYRCh. 23 - Prob. 8BYMVCh. 23 - pyelo-Ch. 23 - Prob. 10BYMVCh. 23 - Prob. 6WWTSCh. 23 - Prob. 7WWTSCh. 23 - The minimum osmolarity of urine is 300 mOsm/L,...Ch. 23 - Prob. 9WWTSCh. 23 - Prob. 10WWTSCh. 23 - Prob. 1BYMVCh. 23 - Prob. 2BYMVCh. 23 - Prob. 3BYMVCh. 23 - Prob. 4BYMVCh. 23 - Prob. 5BYMVCh. 23 - Prob. 6BYMVCh. 23 - Prob. 7BYMVCh. 23 - Prob. 1TYRCh. 23 - The compact ball of capillaries in a nephron is...Ch. 23 - Prob. 3TYRCh. 23 - Prob. 4TYRCh. 23 - Most sodium is reabsorbed from the glomerular...Ch. 23 - Prob. 6TYRCh. 23 - Prob. 7TYRCh. 23 - Prob. 8TYRCh. 23 - Prob. 1WWTSCh. 23 - Prob. 2WWTSCh. 23 - Prob. 3WWTSCh. 23 - Tight junctions prevent material from leaking...Ch. 23 - Prob. 5WWTSCh. 23 - Prob. 1TYCCh. 23 - Prob. 2TYCCh. 23 - Prob. 3TYCCh. 23 - Drugs called renin inhibitors are used to treat...Ch. 23 - Prob. 5TYC
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