Chapter 23, Problem 37P

Interpretation Introduction

Interpretation:

It should be explained how ${\text{NAD}}^{\text{+}}$ oxidize the reduced flavoenzyme in the pyruvate dehydrogenase complex.

Concept introduction:

Vitamin is the coenzymes for the enzymes that catalyses the carboxylation of the carbon of glutamate side chains, a reaction required for blood clotting.

A suicide inhibitor inactive enzymes by taking part in the catalytic mechanism.  A competitive inhibitor inactive an enzymes by competing with the substrate for binding at the active site of the enzymes.

In an enzyme – catalysed reaction that requires coenzymes${\text{B}}_{12}$, a group bonded to one carbon changes places with a hydrogen bonded to an adjacent carbanion.

Biotin (vitamin H) is the coenzyme required by enzymes that catalyse the carboxylation of a carbon adjacent to carbonyl group.

Coenzymes${\text{B}}_{12}$: the coenzyme required by enzymes catalyses certain rearrangement reactions.