Organic Chemistry (8th Edition)
8th Edition
ISBN: 9780134042282
Author: Paula Yurkanis Bruice
Publisher: PEARSON
expand_more
expand_more
format_list_bulleted
Concept explainers
Videos
Textbook Question
Chapter 23, Problem 34P
In addition to the reaction mentioned in Section 23.5. PLP can catalyze β-substitution reactions. Propose a mechanism for the following PLP-catalyzed β-substitution reaction:
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
What are the similarities between β oxidations of heptadecanoic acids (C 17:0), and cis-Δ9-heptadencanoic acids (C 17:1).
Which is true about the ß-lactam compounds?
their pharmacophore has five-membered ring structure
they work only on Gram-negative bacteria
O they work as inhibitor in cell membrane synthesis
O they are irreversible inhibitors of the bacterial serine protease
Triosephosphate isomerase (TIM) catalyzes the conversion of dihydroxyacetone phosphate to glyceraldehyde-3-phosphate. The enzyme’s catalytic groups are Glu 165 and His 95. In the first step of the reaction, these catalytic groups function as a general-base and a general-acid catalyst, respectively. Propose a mechanism for the reaction.
Chapter 23 Solutions
Organic Chemistry (8th Edition)
Ch. 23.1 - Prob. 2PCh. 23.1 - Prob. 3PCh. 23.2 - How many conjugated double bonds are there in a....Ch. 23.2 - Instead of adding to the 4a position and...Ch. 23.2 - Prob. 7PCh. 23.3 - Prob. 8PCh. 23.3 - Acetolactate synthase is another TPP-requiring...Ch. 23.3 - Acetolactate synthase transfers the acyl group of...Ch. 23.3 - Prob. 12PCh. 23.5 - Which compound is more easily decarboxylated?
Ch. 23.5 - Prob. 14PCh. 23.5 - Explain why the ability of PLP to catalyze an...Ch. 23.5 - Explain why the ability of PLP to catalyze an...Ch. 23.5 - The enzyme that catalyzes the C C bond cleavage...Ch. 23.5 - Propose a mechanism for the ,-elimination reaction...Ch. 23.6 - Ethanolamine ammonia lyase, a coenzyme...Ch. 23.6 - Prob. 20PCh. 23.7 - How do the structure of tetrahydrofolate and...Ch. 23.7 - What is the source of the methyl group in...Ch. 23.8 - Thiols such as ethanethiol and propanethiol can be...Ch. 23 - How does the metal ion in carboxypeptidase A...Ch. 23 - Prob. 24PCh. 23 - Prob. 25PCh. 23 - For each of the following reactions, name both the...Ch. 23 - Prob. 27PCh. 23 - When transaminated, the three branched-chain amino...Ch. 23 - What acyl groups have we seen transferred by...Ch. 23 - Propose a mechanism for the following reaction:Ch. 23 - Draw the products of the following reaction, where...Ch. 23 - When UMP is dissolved in T2O, exchange of T for H...Ch. 23 - Dehydratase is a PLP-requiring enzyme that...Ch. 23 - In addition to the reaction mentioned in Section...Ch. 23 - PLP can catalyze both ,-elimination reactions...Ch. 23 - The glycine cleavage system is a group of four...Ch. 23 - Prob. 37PCh. 23 - FADH2 reduces , -unsaturated thioesters to...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.Similar questions
- Choose among these options Among these Inhibits the enzyme which is responsible for the assembly of matured viral particles Saquinavir Didanosine Penciclovir Azidothymidine The following are essential components in the structure of sulfonamides with the exception of Amino group Benzene ring Pyridine N-Acyl amino This drug has been associated with optic neuritis and therefore discontinued after 2 months of treatment Isonizaid Rifampicin Ethambutol Pyrazinamide A non prodrug ACE Inhibitor Captopril Enalapril Quinapril Fosinopril High sodium diet High fat diet Low potassium diet Low phosphate dietarrow_forwardIdentify its componentsarrow_forwardmatch the following vitamins to their functionarrow_forward
- Using the following as possible steps in a pathway: 2 ClF (g) + O2 (g) → Cl2O (g) + OF2 (g) ΔH° = 167.5 kJ 2 OF2 (g) → 2 F2 (g) + O2 (g) ΔH° = 43.5 kJ 2 ClF3 (l) + 2 O2 (g) → Cl2O (g) + 3 OF2 (g) ΔH° = 394.1 kJ Determine a ΔH° for the reaction of gaseous chlorine monofluoride with gaseous fluorine to produce liquid chlorine trifluoride. Balance with the lowest whole number coefficients. Place your answer in the box provided.arrow_forwardWhich of the following compounds is a weak electrolyte?arrow_forwardWhat is the molecular Shape of the Pharmacutical drug Ativan?arrow_forward
- 10. Enumerate the PUFA (Polyunsaturated Fatty Acids) and indicate the position of unsaturation? 11. Enumerate the derivatives of steroids and their functions. 12. Compare and contrast the functions lipoproteins. 13. Circle the fatty acid in each pair that has the higher melting temperature. (a) 18:1Δ9 18:2 Δ 9,12 (b) 18:0 18:1 Δ 9 (c) 18:0 16:0 14. Describe the dependence of the melting point of a fatty acid upon (a) chain length and (b) unsaturation; (c) explain these dependencies in molecular terms.arrow_forwardHow would you describe the glycosidic bond in the following molecule? OH OH HOH H 0- H. но H ОН Он Н H OH OH H. alpha-1,4- beta-1,4- alpha-1,6- beta-1,6- none of thesearrow_forwardDon't give handwritten answersarrow_forward
- Please answer the question below:arrow_forwardPlease draw by hand. Triosephosphate isomerase (TIM) catalyzes the conversion of dihydroxyacetone phosphate to glyceraldehyde-3-phosphate. The enzyme's catalytic groups are Glu 165 and His 95. In the first step of the reaction, these catalytic groups function as a base and an acid catalyst, respectively. Propose a mechanism for the reaction. ОН 2-03Р0 ОН dihydroxyacetone phosphate triosephosphate isomerase 2-03РО. H glyceraldehyde-3-phosphate FYI Glu is glutamic acid and his is histadinearrow_forward21-44 Describe the difference in structure between the male hormone testosterone and the female hormone estradiol.arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Introduction to General, Organic and BiochemistryChemistryISBN:9781285869759Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar TorresPublisher:Cengage Learning
Organic ChemistryChemistryISBN:9781305580350Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. FootePublisher:Cengage Learning
Chemistry for Today: General, Organic, and Bioche...ChemistryISBN:9781305960060Author:Spencer L. Seager, Michael R. Slabaugh, Maren S. HansenPublisher:Cengage Learning
General, Organic, and Biological ChemistryChemistryISBN:9781285853918Author:H. Stephen StokerPublisher:Cengage Learning
Organic And Biological ChemistryChemistryISBN:9781305081079Author:STOKER, H. Stephen (howard Stephen)Publisher:Cengage Learning,
Introduction to General, Organic and Biochemistry
Chemistry
ISBN:9781285869759
Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Publisher:Cengage Learning
Organic Chemistry
Chemistry
ISBN:9781305580350
Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:Cengage Learning
Chemistry for Today: General, Organic, and Bioche...
Chemistry
ISBN:9781305960060
Author:Spencer L. Seager, Michael R. Slabaugh, Maren S. Hansen
Publisher:Cengage Learning
General, Organic, and Biological Chemistry
Chemistry
ISBN:9781285853918
Author:H. Stephen Stoker
Publisher:Cengage Learning
Organic And Biological Chemistry
Chemistry
ISBN:9781305081079
Author:STOKER, H. Stephen (howard Stephen)
Publisher:Cengage Learning,
DIGESTER-35 | VITAMINS AND THEIR RELATED COENZYMES| GPAT | NIPER | PHARMACIST| DI; Author: GPAT DISCUSSION CENTER;https://www.youtube.com/watch?v=CGrdNYmho0s;License: Standard YouTube License, CC-BY