Anatomy & Physiology
1st Edition
ISBN: 9781938168130
Author: Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Publisher: OpenStax College
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Chapter 23, Problem 36CTQ
It has been several hours since you last ate. Walking past a bakery, you catch a whiff of freshly baked bread. What type of reflex is triggered, and what is the result?
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 23 Solutions
Anatomy & Physiology
Ch. 23 - By clicking on this link...Ch. 23 - Visit this site...Ch. 23 - Watch this animation...Ch. 23 - Watch this animation...Ch. 23 - Watch this animation...Ch. 23 - By watching this animation...Ch. 23 - Watch this video...Ch. 23 - Which of these organs is not considered an...Ch. 23 - Which of the following organs is supported by a...Ch. 23 - Which of the following membranes covers the...
Ch. 23 - Which of these processes occurs in the mouth?...Ch. 23 - Which of these processes occurs throughout most of...Ch. 23 - Which of the following stimuli activates sensors...Ch. 23 - Which of these statements about reflexes in the GI...Ch. 23 - Which of these ingredients in saliva is...Ch. 23 - Which of these statements about the pharynx is...Ch. 23 - Which structure is located where the esophagus...Ch. 23 - Which phase of deglutition involves contraction of...Ch. 23 - Which of these cells secrete hormones? parietal...Ch. 23 - Where does the majority of chemical digestion in...Ch. 23 - During gastric emptying, chyme is released into...Ch. 23 - Parietal cells secrete ________. gastrin...Ch. 23 - In which pail of the alimentary canal does most...Ch. 23 - Which of these is most associated with villi?...Ch. 23 - What is the roLe of the small intestines MALT?...Ch. 23 - Which part of the large intestine attaches to the...Ch. 23 - Which of these statements about bile is true?...Ch. 23 - Pancreatic juice ________. deactivates bile. is...Ch. 23 - Where does the chemical digestion of starch begin?...Ch. 23 - Which of these is involved in the chemical...Ch. 23 - Where are most fat-digesting enzymes produced?...Ch. 23 - Which of these nutrients is absorbed mainly in the...Ch. 23 - Explain how the enteric nervous system supports...Ch. 23 - What layer of the alimentary canal tissue is...Ch. 23 - Offer a theory to explain why segmentation occurs...Ch. 23 - It has been several hours since you last ate....Ch. 23 - The composition of saliva varies from gland to...Ch. 23 - During a hockey game, the puck hits a player in...Ch. 23 - What prevents swallowed food from entering the...Ch. 23 - Explain the mechanism responsible for...Ch. 23 - Describe the three processes involved in the...Ch. 23 - Explain how the stomach is protected from self...Ch. 23 - Describe unique anatomical features that enable...Ch. 23 - Explain how nutrients absorbed in the small...Ch. 23 - Why is it important that chyme from the stomach is...Ch. 23 - Describe three of the differences between the...Ch. 23 - Why does the pancreas secrete some enzymes in...Ch. 23 - Describe the location of hepatocytes in the liver...Ch. 23 - Explain the role of bile salts and lecithin in the...Ch. 23 - How is vitamin B12 absorbed?
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