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Chapter 23, Problem 23.48EP

(a)

Interpretation Introduction

Interpretation: To draw the structural formula for fumaric acid.

Concept introduction: There are a number of metabolic reaction that occur in the human body for completion of functions. During these metabolic reactions, the various metabolic intermediates are formed for the short time to complete the reactions. Polyfunctional carboxylate ions are also the metabolic intermediate formed during metabolic pathways.

Polyfunctional carboxylate ions act as a substrate in the metabolic pathways and can be divided into two parts depending upon the parent carboxylic acid. The two parent carboxylic acids are succinic acid and glutaric acid.

Fumaric acid is an unsaturated derivative of succinic acid. The structure of succinic acid is:

Bundle: General, Organic, and Biological Chemistry, 7th + OWLv2 Quick Prep for General Chemistry, 4 terms (24 months) Printed Access Card, Chapter 23, Problem 23.48EP , additional homework tip  1

(b)

Interpretation Introduction

Interpretation: To draw the structural formula for fumarate ion.

Concept introduction: There are a number of metabolic reaction that occur in the human body for completion of functions. During these metabolic reactions, the various metabolic intermediates are formed for the short time to complete the reactions. Polyfunctional carboxylate ions are also the metabolic intermediate formed during metabolic pathways.

Polyfunctional carboxylate ions act as a substrate in the metabolic pathways and can be divided into two parts depending upon the parent carboxylic acid. The two parent carboxylic acids are succinic acid and glutaric acid.

(c)

Interpretation Introduction

Interpretation: To draw the structural formula for malic acid.

Concept introduction: There are a number of metabolic reaction that occur in the human body for completion of functions. During these metabolic reactions, the various metabolic intermediates are formed for the short time to complete the reactions. Polyfunctional carboxylate ions are also the metabolic intermediate formed during metabolic pathways.

Polyfunctional carboxylate ions act as a substrate in the metabolic pathways and can be divided into two parts depending upon the parent carboxylic acid. The two parent carboxylic acids are succinic acid and glutaric acid.

Malic acid is an unsaturated derivative of succinic acid. The structure of succinic acid is:

Bundle: General, Organic, and Biological Chemistry, 7th + OWLv2 Quick Prep for General Chemistry, 4 terms (24 months) Printed Access Card, Chapter 23, Problem 23.48EP , additional homework tip  2

(d)

Interpretation Introduction

Interpretation: To draw the structural formula for malate ion.

Concept introduction: There are a number of metabolic reaction that occur in the human body for completion of functions. During these metabolic reactions, the various metabolic intermediates are formed for the short time to complete the reactions. Polyfunctional carboxylate ions are also the metabolic intermediate formed during metabolic pathways.

Polyfunctional carboxylate ions act as a substrate in the metabolic pathways and can be divided into two parts depending upon the parent carboxylic acid. The two parent carboxylic acids are succinic acid and glutaric acid. The first class consists of malate, oxaloacetate and fumarate ion which are derivative of succinic acid. The second class consists of αketoglutarate and citrate ion which is a derivative of glutaric acid

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a. What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent.  b. What will happen to elimination of the drug in the previous question if the system is saturated? explain and show any math involved
If you wanted to reduce the difference between peak and trough levels that occur with repeated administration of a drug, how would you adjust the dose and dose interval without changing the plateau concentration (plateau is the average of peak and trough levels)? Select your answers for both dose and interval. Hint: It may be helpful to think about this problem using an example such as food. How would you eat if you wanted to maintain very steady hunger/satiety levels without changing your total caloric intake? Options: A. Dose; Increase dose     B. Dose; Decrease dose     C. Dose; Do not change dose     D. Interval; Increase the interval between doses (give the drug less frequently)    E. Interval; Decrease the interval between doses (give the drug more frequently)     F. Interval; Do not change the interval
What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent. Show the math

Chapter 23 Solutions

Bundle: General, Organic, and Biological Chemistry, 7th + OWLv2 Quick Prep for General Chemistry, 4 terms (24 months) Printed Access Card

Ch. 23.3 - Which of the following statements concerning...Ch. 23.4 - Prob. 1QQCh. 23.4 - Prob. 2QQCh. 23.5 - Prob. 1QQCh. 23.5 - Prob. 2QQCh. 23.5 - Prob. 3QQCh. 23.6 - Which of the following occurs in the second stage...Ch. 23.6 - Which of the following stages in the biochemical...Ch. 23.6 - Prob. 3QQCh. 23.7 - Prob. 1QQCh. 23.7 - Prob. 2QQCh. 23.7 - Prob. 3QQCh. 23.7 - How many NADH and FADH2 molecules are produced,...Ch. 23.7 - Which of the following citric acid cycle...Ch. 23.7 - In which of the following listings of citric acid...Ch. 23.8 - Which of the following is a fuel for the electron...Ch. 23.8 - Prob. 2QQCh. 23.8 - What is the substrate that initially interacts...Ch. 23.8 - The number of fixed enzyme sites in the electron...Ch. 23.8 - In which of the following listings of electron...Ch. 23.8 - Prob. 6QQCh. 23.9 - How many of the four enzyme complexes in the...Ch. 23.9 - Prob. 2QQCh. 23.9 - Prob. 3QQCh. 23.10 - Prob. 1QQCh. 23.10 - Prob. 2QQCh. 23.11 - Prob. 1QQCh. 23.11 - Prob. 2QQCh. 23.11 - Prob. 3QQCh. 23.12 - Prob. 1QQCh. 23.12 - Prob. 2QQCh. 23 - Classify anabolism and catabolism as synthetic or...Ch. 23 - Classify anabolism and catabolism as...Ch. 23 - What is a metabolic pathway?Ch. 23 - Prob. 23.4EPCh. 23 - Classify each of the following processes as...Ch. 23 - Classify each of the following processes as...Ch. 23 - Prob. 23.7EPCh. 23 - Prob. 23.8EPCh. 23 - Prob. 23.9EPCh. 23 - Indicate whether each of the following statements...Ch. 23 - Prob. 23.11EPCh. 23 - Prob. 23.12EPCh. 23 - Prob. 23.13EPCh. 23 - Prob. 23.14EPCh. 23 - Specify, by name and by number present, the...Ch. 23 - Prob. 23.16EPCh. 23 - Prob. 23.17EPCh. 23 - Prob. 23.18EPCh. 23 - Prob. 23.19EPCh. 23 - Prob. 23.20EPCh. 23 - Prob. 23.21EPCh. 23 - Prob. 23.22EPCh. 23 - Write a generalized chemical equation, containing...Ch. 23 - Prob. 23.24EPCh. 23 - Prob. 23.25EPCh. 23 - Prob. 23.26EPCh. 23 - Draw each of the following types of block diagrams...Ch. 23 - Prob. 23.28EPCh. 23 - What is the name of the B vitamin present in each...Ch. 23 - Prob. 23.30EPCh. 23 - Prob. 23.31EPCh. 23 - Prob. 23.32EPCh. 23 - Prob. 23.33EPCh. 23 - Prob. 23.34EPCh. 23 - Prob. 23.35EPCh. 23 - Prob. 23.36EPCh. 23 - Prob. 23.37EPCh. 23 - Prob. 23.38EPCh. 23 - Prob. 23.39EPCh. 23 - Prob. 23.40EPCh. 23 - Prob. 23.41EPCh. 23 - Prob. 23.42EPCh. 23 - Prob. 23.43EPCh. 23 - Prob. 23.44EPCh. 23 - Prob. 23.45EPCh. 23 - Prob. 23.46EPCh. 23 - Prob. 23.47EPCh. 23 - Prob. 23.48EPCh. 23 - Prob. 23.49EPCh. 23 - Prob. 23.50EPCh. 23 - Prob. 23.51EPCh. 23 - Prob. 23.52EPCh. 23 - Prob. 23.53EPCh. 23 - Prob. 23.54EPCh. 23 - Prob. 23.55EPCh. 23 - Prob. 23.56EPCh. 23 - Prob. 23.57EPCh. 23 - Prob. 23.58EPCh. 23 - List, by name, the four general stages of the...Ch. 23 - Prob. 23.60EPCh. 23 - Prob. 23.61EPCh. 23 - Prob. 23.62EPCh. 23 - Prob. 23.63EPCh. 23 - Prob. 23.64EPCh. 23 - Prob. 23.65EPCh. 23 - Prob. 23.66EPCh. 23 - Prob. 23.67EPCh. 23 - Prob. 23.68EPCh. 23 - Prob. 23.69EPCh. 23 - Prob. 23.70EPCh. 23 - Prob. 23.71EPCh. 23 - Prob. 23.72EPCh. 23 - Prob. 23.73EPCh. 23 - Prob. 23.74EPCh. 23 - Prob. 23.75EPCh. 23 - Prob. 23.76EPCh. 23 - Prob. 23.77EPCh. 23 - Prob. 23.78EPCh. 23 - Prob. 23.79EPCh. 23 - Prob. 23.80EPCh. 23 - Prob. 23.81EPCh. 23 - Prob. 23.82EPCh. 23 - Prob. 23.83EPCh. 23 - Prob. 23.84EPCh. 23 - Prob. 23.85EPCh. 23 - Prob. 23.86EPCh. 23 - Prob. 23.87EPCh. 23 - Prob. 23.88EPCh. 23 - Indicate whether each of the following changes...Ch. 23 - Prob. 23.90EPCh. 23 - Prob. 23.91EPCh. 23 - Prob. 23.92EPCh. 23 - Which electron carrier shuttles electrons between...Ch. 23 - Prob. 23.94EPCh. 23 - Prob. 23.95EPCh. 23 - Prob. 23.96EPCh. 23 - Prob. 23.97EPCh. 23 - Prob. 23.98EPCh. 23 - Prob. 23.99EPCh. 23 - Prob. 23.100EPCh. 23 - Put the following substances in the correct order...Ch. 23 - Prob. 23.102EPCh. 23 - Prob. 23.103EPCh. 23 - Prob. 23.104EPCh. 23 - Prob. 23.105EPCh. 23 - Prob. 23.106EPCh. 23 - Prob. 23.107EPCh. 23 - Prob. 23.108EPCh. 23 - Prob. 23.109EPCh. 23 - Prob. 23.110EPCh. 23 - How many protons cross the inner mitochondrial...Ch. 23 - How many protons cross the inner mitochondrial...Ch. 23 - Prob. 23.113EPCh. 23 - Prob. 23.114EPCh. 23 - Prob. 23.115EPCh. 23 - Prob. 23.116EPCh. 23 - Prob. 23.117EPCh. 23 - Prob. 23.118EPCh. 23 - Prob. 23.119EPCh. 23 - Prob. 23.120EPCh. 23 - Prob. 23.121EPCh. 23 - Prob. 23.122EPCh. 23 - Prob. 23.123EPCh. 23 - Prob. 23.124EPCh. 23 - Prob. 23.125EPCh. 23 - Prob. 23.126EPCh. 23 - Prob. 23.127EPCh. 23 - Prob. 23.128EPCh. 23 - Indicate whether or not each of the following B...Ch. 23 - Prob. 23.130EPCh. 23 - Prob. 23.131EPCh. 23 - Prob. 23.132EP
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