Life: The Science of Biology
Life: The Science of Biology
11th Edition
ISBN: 9781319010164
Author: David E. Sadava, David M. Hillis, H. Craig Heller, Sally D. Hacker
Publisher: W. H. Freeman
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Chapter 22.2, Problem 1R
Summary Introduction

To review:

As per the Dobzhansky-Muller model, the divergence in the alleles at different gene loci leads to genetic incompatibility between the species. It needs to study the incompatibility which is less likely at the same locus between two alleles.

Given:

It is given that Dobzhansky-Muller model suggests that the divergence in the alleles is seen at different loci of a gene which can lead to genetic incompatibility between the species that possess such genes.

Introduction:

Dobzhansky-Muller model is a two-locus version model which studies the changes between the two lineages are from the same ancestor population, which gets divided from each other and evolve on their own. The new allele that generates, it becomes fixed in each descendent but the locus of the two alleles becomes different.

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Digoxin: Intravenous Bolus - Two Compartment Model Drug Digoxin Route: IV Bolus Dose: 0.750 mg Plasma Concentration Time Profile Beta Alpha Time (hrs) Conc (ng/ml) LN (ng/ml) LN (ng/ml) LN 0.00 #NUM! #NUM! #NUM! 0.10 12.290 2.509 #NUM! #NUMI 0.60 6.975 1.942 #NUM! #NUMI 1.00 4.649 1.537 #NUM! #NUMI 2.00 2.201 0.789 #NUM! #NUM! 3.00 1.536 0.429 #NUM! #NUM! 4.00 1.342 0.294 #NUM! #NUM! 5.00 1.273 0.241 #NUM! #NUMI 6.00 1.238 0.213 #NUM! #NUM! 7.00 1.212 0.192 #NUM! #NUM! 8.00 1.188 0.172 #NUMI #NUM! 9.00 1.165 0.153 #NUM! #NUMI 10.00 1.143 0.134 #NUMI #NUM! 11.00 1.122 0.115 #NUM! 12.00 1.101 0.096 #NUMI 13.00 1.080 0.077 #NUMI 16.00 1.020 0.020 #NUMI 24.00 0.876 -0.132 #NUMI Pharmacokinetic Parameters Parameter Value Alpha B Beta Units ng/ml hr-1 ng/ml hr-1 CO ng/ml H.C AUC ng x hr/ml Vc Vbeta Vss C L/hr TK (alpha) hr TX (beta) days 5+ F3 F4 F5 0+ F6 F7 % 6 95 14 #3 29 & t F8 F9 FW EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg rabbits following a bolus IV injection of 10mg/kg. Time (minutes) Serum Linuron Levels (ug/ml) following IV dose 10 15.48 20 8.60 30 5.90 45 3.78 60 2.42 90 1.49 120 0.93 180 0.60 240 0.41 300 0.29 360 0.22 Analyze this data and perform the necessary calculations to determine the following pharmacokinetic parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points possible). You do NOT need to submit graphs or data tables. Give the terminal regression line equation and R or R² value: Give the x axis (name and units, if any) of the terminal line: Give the y axis (name and units, if any) of the terminal line: Give the residual regression line equation and R or R² value: Give the x axis (name and units, if any) of the residual line: Give the y axis (name and units, if any) of the residual line:
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