The preparation of the given compound from benzene, ammonia and other reagents has to be achieved via epoxide formation Concept Introduction : Reductive amination: Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines . Friedel–Crafts Acylation: The Friedel–Crafts acylation is the reaction of an arene with acyl chlorides or anhydrides using a strong Lewis acid catalyst. This reaction proceeds via electrophilic aromatic substitution to form monoacylated products. Grignard reaction : The Grignard reaction is an organic reaction used to create a variety of products through the reaction of an organomagnesium compound, also known as a "Grignard reagent" with an electrophile, followed by acid work-up. Concentrated sulfuric acid acts as a dehydrating agent. Concentrated sulfuric acid and heat remove a water molecule in a compound. Peroxy acid forms an epoxide with an alkene . Primary or secondary amines will attack epoxides in a ring-opening process. For substituted epoxides, nucleophilic attack generally takes place at the less sterically hindered side of the epoxide. To find: Prepare the given compound from benzene, ammonia and other reagents via epoxide formation Apply a retrosynthetic analysis

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Answer 1

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Definition Definition Organic compounds that have a carbonyl group, C=O, as their functional group. The carbonyl group in aldehydes is placed at the end of the molecular structure, which means the C=O is attached to one hydrogen atom and an alkyl group or a benzene ring. Just like all the other homologous series in organic chemistry, the naming of aldehydes uses the suffix “-al”. The general molecular formula is C n H 2n O.

Chapter 22, Problem 76IP

Interpretation Introduction

Interpretation: The preparation of the given compound from benzene, ammonia and other reagents has to be achieved via epoxide formation

Concept Introduction:

Reductive amination: Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Friedel–Crafts Acylation: The Friedel–Crafts acylation is the reaction of an arene with acyl chlorides or anhydrides using a strong Lewis acid catalyst. This reaction proceeds via electrophilic aromatic substitution to form monoacylated products.

Grignard reaction: The Grignard reaction is an organic reaction used to create a variety of products through the reaction of an organomagnesium compound, also known as a "Grignard reagent" with an electrophile, followed by acid work-up.

Concentrated sulfuric acid acts as a dehydrating agent. Concentrated sulfuric acid and heat remove a water molecule in a compound. Peroxy acid forms an epoxide with an alkene. Primary or secondary amines will attack epoxides in a ring-opening process. For substituted epoxides, nucleophilic attack generally takes place at the less sterically hindered side of the epoxide.

To find: Prepare the given compound from benzene, ammonia and other reagents via epoxide formation

Apply a retrosynthetic analysis

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Answer 2

Question

Definition Definition Organic compounds that have a carbonyl group, C=O, as their functional group. The carbonyl group in aldehydes is placed at the end of the molecular structure, which means the C=O is attached to one hydrogen atom and an alkyl group or a benzene ring. Just like all the other homologous series in organic chemistry, the naming of aldehydes uses the suffix “-al”. The general molecular formula is C n H 2n O.

Chapter 22, Problem 76IP

Interpretation Introduction

Interpretation: The preparation of the given compound from benzene, ammonia and other reagents has to be achieved via epoxide formation

Concept Introduction:

Reductive amination: Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Friedel–Crafts Acylation: The Friedel–Crafts acylation is the reaction of an arene with acyl chlorides or anhydrides using a strong Lewis acid catalyst. This reaction proceeds via electrophilic aromatic substitution to form monoacylated products.

Grignard reaction: The Grignard reaction is an organic reaction used to create a variety of products through the reaction of an organomagnesium compound, also known as a "Grignard reagent" with an electrophile, followed by acid work-up.

Concentrated sulfuric acid acts as a dehydrating agent. Concentrated sulfuric acid and heat remove a water molecule in a compound. Peroxy acid forms an epoxide with an alkene. Primary or secondary amines will attack epoxides in a ring-opening process. For substituted epoxides, nucleophilic attack generally takes place at the less sterically hindered side of the epoxide.

To find: Prepare the given compound from benzene, ammonia and other reagents via epoxide formation

Apply a retrosynthetic analysis

Expert Solution & Answer

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Check out a sample textbook solution

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Answer 3

Question

Definition Definition Organic compounds that have a carbonyl group, C=O, as their functional group. The carbonyl group in aldehydes is placed at the end of the molecular structure, which means the C=O is attached to one hydrogen atom and an alkyl group or a benzene ring. Just like all the other homologous series in organic chemistry, the naming of aldehydes uses the suffix “-al”. The general molecular formula is C n H 2n O.

Chapter 22, Problem 76IP

Interpretation Introduction

Interpretation: The preparation of the given compound from benzene, ammonia and other reagents has to be achieved via epoxide formation

Concept Introduction:

Reductive amination: Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Friedel–Crafts Acylation: The Friedel–Crafts acylation is the reaction of an arene with acyl chlorides or anhydrides using a strong Lewis acid catalyst. This reaction proceeds via electrophilic aromatic substitution to form monoacylated products.

Grignard reaction: The Grignard reaction is an organic reaction used to create a variety of products through the reaction of an organomagnesium compound, also known as a "Grignard reagent" with an electrophile, followed by acid work-up.

Concentrated sulfuric acid acts as a dehydrating agent. Concentrated sulfuric acid and heat remove a water molecule in a compound. Peroxy acid forms an epoxide with an alkene. Primary or secondary amines will attack epoxides in a ring-opening process. For substituted epoxides, nucleophilic attack generally takes place at the less sterically hindered side of the epoxide.

To find: Prepare the given compound from benzene, ammonia and other reagents via epoxide formation

Apply a retrosynthetic analysis

Expert Solution & Answer

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Check out a sample textbook solution

See solution

Answer 4

Question

Definition Definition Organic compounds that have a carbonyl group, C=O, as their functional group. The carbonyl group in aldehydes is placed at the end of the molecular structure, which means the C=O is attached to one hydrogen atom and an alkyl group or a benzene ring. Just like all the other homologous series in organic chemistry, the naming of aldehydes uses the suffix “-al”. The general molecular formula is C n H 2n O.

Chapter 22, Problem 76IP

Interpretation Introduction