Anatomy & Physiology
1st Edition
ISBN: 9781938168130
Author: Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Publisher: OpenStax College
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Textbook Question
Chapter 22, Problem 49CTQ
Describe the neural factors involved in increasing ventilation during exercise.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
List substitutions in your diet you could make to improve it based on what you know now about a balanced diet. For instance, if you like to drink soda, you might substitute skim milk or water for some of the soft drinks you consumed. List the item you wish to replace with the new item and what you hope to accomplish with that substitution. Be sure to choose foods you know that you'd enjoy and you consider more "healthful." If you feel your diet is already balanced, describe how you accomplish your balanced intake and when you began eating this way.
Chapter 22 Solutions
Anatomy & Physiology
Ch. 22 - Visit this site...Ch. 22 - Watch this video...Ch. 22 - Watch this video...Ch. 22 - Which of the following anatomical structures is...Ch. 22 - What is the function of the conchae in the nasal...Ch. 22 - The fauces connects which of the following...Ch. 22 - Which of the following are structural features of...Ch. 22 - Which of the following structures is not part of...Ch. 22 - What is the role of alveolar macrophages? to...Ch. 22 - Which of the following structures separates the...
Ch. 22 - A section of the lung that receives its own...Ch. 22 - The ________ circulation picks up oxygen for...Ch. 22 - The pleura that surrounds the lungs consists of...Ch. 22 - Which of the following processes does atmospheric...Ch. 22 - A decrease in volume leads to a(n) ________...Ch. 22 - The pressure difference between the intra-alveolar...Ch. 22 - Gas flow decreases as ________ increases....Ch. 22 - Contraction of the external intercostal muscles...Ch. 22 - Which of the following prevents the alveoli from...Ch. 22 - Gas moves from an area of ________ partial...Ch. 22 - When ventilation is not sufficient, which of the...Ch. 22 - Gas exchange that occurs at the level of the...Ch. 22 - The partial pressure of carbon dioxide is 45 mm Hg...Ch. 22 - Oxyhemoglobin forms by a chemical reaction between...Ch. 22 - Which of the following factors play a role in the...Ch. 22 - Which of the following occurs during the chloride...Ch. 22 - A low partial pressure of oxygen promotes...Ch. 22 - Increased ventilation that results in an increase...Ch. 22 - Exercise can trigger symptoms of AMS due to which...Ch. 22 - Which of the following stimulates the production...Ch. 22 - The olfactory pits form from which of the...Ch. 22 - A full complement of mature alveoli are present by...Ch. 22 - If a baby is bom prematurely before type II cells...Ch. 22 - When do fetal breathing movements begin? around...Ch. 22 - What happens to the fluid that remains in the...Ch. 22 - Describe the three regions of the pharynx and...Ch. 22 - If a person sustains an injury to the epiglottis,...Ch. 22 - Compare and contrast the conducting and...Ch. 22 - Compare and contrast the right and left lungs.Ch. 22 - Why are the pleurae not damaged during normal...Ch. 22 - Describe what is meant by the term lung...Ch. 22 - Outline the steps involved in quiet breathing.Ch. 22 - What is respiratory rate and how is it controlled?Ch. 22 - Compare and contrast Daltons law and Henrys law.Ch. 22 - A smoker develops damage to several alveoli that...Ch. 22 - Compare and contrast adult hemoglobin and fetal...Ch. 22 - Describe the relationship between the partial...Ch. 22 - Describe three ways in which carbon dioxide can be...Ch. 22 - Describe the neural factors involved in increasing...Ch. 22 - What is the major mechanism that results in...Ch. 22 - Dining what timeframe does a fetus have enough...Ch. 22 - Describe fetal breathing movements and their...
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