Chapter 22, Problem 46P

Interpretation Introduction

Interpretation:

The allosteric effect of citrate on acetyl CoA carboxylase should be determined along with the effect of palmitoyl CoA on acetyl CoA carboxylase.

Concept introduction:

Acetyl-CoA carboxylase (ACC) is a biotin-dependent enzyme, which catalyzes the conversion of acetyl-CoA into malonyl-CoA, in the presence of bicarbonate ion. It has two catalytic activities, carboxyl transferase and biotin carboxylase. This enzyme is found in the chloroplasts of the plants, and endoplasmic reticulum of the animals. The main motive of ACC is to synthesize malonyl CoA for the synthesis of fatty acids.