Concepts of Genetics (11th Edition)
11th Edition
ISBN: 9780321948915
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino
Publisher: PEARSON
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Chapter 22, Problem 26ESP
Summary Introduction
To determine: The reason due to which mouse did not show lung congestion symptoms of cystic fibrosis.
Introduction: Cystic fibrosis (CF) is an autosomal recessive disease. The disease condition would appear only when an individual has a homozygous recessive (aa) gene for this disorder. This condition causes respiratory tract problems in case of human beings.
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Chapter 22 Solutions
Concepts of Genetics (11th Edition)
Ch. 22 - In order to vaccinate people against diseases by...Ch. 22 - Prob. 2NSTCh. 22 - Prob. 3NSTCh. 22 - Prob. 1CSCh. 22 - Prob. 2CSCh. 22 - Prob. 3CSCh. 22 -
HOW DO WE KNOW?
In this chapter, we focused on a...Ch. 22 -
Review the Chapter Concepts list on page 569....Ch. 22 - Prob. 3PDQCh. 22 - Why are most recombinant human proteins produced...
Ch. 22 - Prob. 5PDQCh. 22 - One of the major causes of sickness, death, and...Ch. 22 - Describe how the team from the J. Craig Venter...Ch. 22 - Prob. 8PDQCh. 22 - Prob. 9PDQCh. 22 - Prob. 10PDQCh. 22 - As genetic testing becomes widespread, medical...Ch. 22 - Prob. 12PDQCh. 22 - Prob. 13PDQCh. 22 - What is the main purpose of genome-wide...Ch. 22 - Prob. 15PDQCh. 22 - Dominant mutations can be categorized according to...Ch. 22 - In 2013 the actress Angelina Jolie elected to have...Ch. 22 - Prob. 18PDQCh. 22 - Should the FDA regulate direct-to-consumer genetic...Ch. 22 - Prob. 20ESPCh. 22 - Following the tragic shooting of 20 children at a...Ch. 22 - Private companies are offering personal DNA...Ch. 22 - Prob. 23ESPCh. 22 - Prob. 24ESPCh. 22 - Prob. 25ESPCh. 22 - Prob. 26ESP
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- Cystic fibrosis (CF) is a genetic disorder affecting a number of organs, including the lung airways, pancreas, and sweat glands. Mutations in both copies of the CFTR gene causes cystic fibrosis. Imagine that you have sweat gland samples from several Cystic Fibrosis patients (A-C) with unknown mutations in CFTR. You also have normal (+) sweat gland sample to use as a positive control. А В С А В С Choose which mutation would explain the RNA and protein results in A, B, & C: 1. Promoter/Regulatory mutation 2. Silent mutation 3. Missense mutation 4. Deletion mutation 5. Splice site mutation 6. Nonsense mutation RNA gel Protein gelarrow_forwardYou decide to use a plaque assay with a human lung epithelial cell line to compare the effectiveness of the drug. The results of the plaque assay for one strain of influenza are shown below. Based on these results, what can you conclude about the relative effectiveness of WJ379 at 1 mM compared to oseltamivir at 1 mM? Briefly explain your rationale.arrow_forwardA wild-type mouse that is heterozygous for two immunoglobulin heavy chain alleles (IgHa/b) generates the population of B cells shown on the left of the figure below. A mouse strain, also IgHa/b, carries an inactivating mutation in the VpreB gene. In addition to producing fewer mature B cells than the wild-type mice, the VpreB-deficient mice generate B cells as shown on the right. What is the explanation of the difference seen between the wild-type and the VpreB-mutant B cells?arrow_forward
- 3.) A number of publications explain an expanding knowledge on the genetics and genomics of SARS-CoV-2 and its implications for understanding COVID-19. Why should a healthcare professional need to have a solid understanding of these basic genetics and genetic engineering terms? How would this knowledge help you in your nursing practice? 4.) Scientists and researchers are using genetic engineering rather than traditional methods in developing COVID-19 vaccines. In a tabular format give at least 2 examples of vaccines that uses genetic technology and describe each in terms of: a. Target Population b. Vaccine Efficacy C. Vaccine administration d. Possible side effects Storage requirements e.arrow_forwardThe genetic alteration responsible for sickle-cell anemia in humans involves: a transition mutation from A to G, substituting glutamic acid for valine in a-globin a transversion mutation from T to A, substituting valine for glutamic acid in b-globin a transition mutation from T to C, substituting valine for glutamic acid in b-globin a transversion mutation from G to C, substituting glutamic acid for valine in a-globin a frameshift mutation of one ATC codon, removing glutamic acid from b-globinarrow_forwardAn individual carries a disease-causing point mutation. Briefly describe four methods that can be used to identify this mutation.arrow_forward
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