ANATOMY & PHYSIOLOGY LL\AC
9th Edition
ISBN: 9781264325948
Author: SALADIN
Publisher: MCG
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Chapter 21.1, Problem 1BYGO
Summary Introduction
Introduction:
The lymphatic system consists of a group of cells or immune cells that inhabit in all the organs of the body. The lymphatic system includes lymphatic organs and group of lymphatic tissues involved in the immune system. The lymphatic organs include spleen, tonsils, thymus, lymph nodes, and bone marrow.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 21 Solutions
ANATOMY & PHYSIOLOGY LL\AC
Ch. 21.1 - Prob. 1BYGOCh. 21.1 - Prob. 2BYGOCh. 21.1 - Prob. 3BYGOCh. 21.1 - Prob. 4BYGOCh. 21.1 - Prob. 5BYGOCh. 21.1 - Prob. 1AYLOCh. 21.1 - Prob. 2AYLOCh. 21.1 - Prob. 3AYLOCh. 21.1 - Prob. 4AYLOCh. 21.1 - Prob. 5AYLO
Ch. 21.1 - Prob. 6AYLOCh. 21.1 - Prob. 7AYLOCh. 21.1 - The nature of diffuse lymphatic tissue and where...Ch. 21.1 - Prob. 9AYLOCh. 21.1 - Prob. 10AYLOCh. 21.1 - Prob. 11AYLOCh. 21.1 - Prob. 12AYLOCh. 21.1 - Prob. 13AYLOCh. 21.1 - Prob. 14AYLOCh. 21.1 - Location, gross anatomy, and histology of the...Ch. 21.2 - Prob. 6BYGOCh. 21.2 - Prob. 7BYGOCh. 21.2 - How do interferons and the complement system...Ch. 21.2 - Prob. 9BYGOCh. 21.2 - List the cardinal signs of inflammation and state...Ch. 21.2 - Prob. 1AYLOCh. 21.2 - Prob. 2AYLOCh. 21.2 - Differences between innate and adaptive immunity;...Ch. 21.2 - Prob. 4AYLOCh. 21.2 - Prob. 5AYLOCh. 21.2 - Prob. 6AYLOCh. 21.2 - The one type of lymphocyte that is involved in...Ch. 21.2 - Types of macrophages; their origin and functionsCh. 21.2 - Prob. 9AYLOCh. 21.2 - Prob. 10AYLOCh. 21.2 - Prob. 11AYLOCh. 21.2 - Prob. 12AYLOCh. 21.2 - Prob. 13AYLOCh. 21.2 - Prob. 14AYLOCh. 21.2 - Prob. 15AYLOCh. 21.2 - Prob. 16AYLOCh. 21.2 - Examples of inflammatory cytokines and their rolesCh. 21.2 - How hyperemia, bradykinin, and other factors...Ch. 21.2 - Prob. 19AYLOCh. 21.2 - Prob. 20AYLOCh. 21.2 - Prob. 21AYLOCh. 21.3 - Prob. 11BYGOCh. 21.3 - Prob. 12BYGOCh. 21.3 - Contrast active and passive immunity. Give natural...Ch. 21.3 - Prob. 14BYGOCh. 21.3 - Prob. 15BYGOCh. 21.3 - Prob. 16BYGOCh. 21.3 - Prob. 17BYGOCh. 21.3 - Prob. 18BYGOCh. 21.3 - Prob. 1AYLOCh. 21.3 - Prob. 2AYLOCh. 21.3 - How adaptive immunity is classified as active or...Ch. 21.3 - Prob. 4AYLOCh. 21.3 - Prob. 5AYLOCh. 21.3 - Prob. 6AYLOCh. 21.3 - Prob. 7AYLOCh. 21.3 - Prob. 8AYLOCh. 21.3 - Prob. 9AYLOCh. 21.3 - Prob. 10AYLOCh. 21.3 - The meanings of immunocompetence and...Ch. 21.3 - Prob. 12AYLOCh. 21.3 - Prob. 13AYLOCh. 21.3 - Prob. 14AYLOCh. 21.4 - Prob. 19BYGOCh. 21.4 - Prob. 20BYGOCh. 21.4 - Prob. 21BYGOCh. 21.4 - Prob. 22BYGOCh. 21.4 - Prob. 1AYLOCh. 21.4 - Prob. 2AYLOCh. 21.4 - Prob. 3AYLOCh. 21.4 - Prob. 4AYLOCh. 21.4 - Prob. 5AYLOCh. 21.4 - How activated Tc cells destroy target cells; the...Ch. 21.4 - Prob. 7AYLOCh. 21.5 - Prob. 23BYGOCh. 21.5 - Prob. 24BYGOCh. 21.5 - Prob. 25BYGOCh. 21.5 - Similarities and differences between humoral and...Ch. 21.5 - Prob. 2AYLOCh. 21.5 - Prob. 3AYLOCh. 21.5 - Prob. 4AYLOCh. 21.5 - Prob. 5AYLOCh. 21.6 - Prob. 26BYGOCh. 21.6 - Prob. 27BYGOCh. 21.6 - Prob. 28BYGOCh. 21.6 - Prob. 29BYGOCh. 21.6 - Prob. 30BYGOCh. 21.6 - Prob. 1AYLOCh. 21.6 - Prob. 2AYLOCh. 21.6 - Prob. 3AYLOCh. 21.6 - Prob. 4AYLOCh. 21.6 - The pathology of acquired immunodeficiency...Ch. 21 - The only lymphatic organ with both afferent and...Ch. 21 - Prob. 2TYRCh. 21 - Prob. 3TYRCh. 21 - Which of these is a macrophage? a. a microglial...Ch. 21 - Prob. 5TYRCh. 21 - Prob. 6TYRCh. 21 - Which of the following correctly stales the order...Ch. 21 - Prob. 8TYRCh. 21 - Prob. 9TYRCh. 21 - Which of the following results from a lack of...Ch. 21 - Any microorganism capable of causing disease is...Ch. 21 - Prob. 12TYRCh. 21 - Prob. 13TYRCh. 21 - Prob. 14TYRCh. 21 - Prob. 15TYRCh. 21 - Prob. 16TYRCh. 21 - Prob. 17TYRCh. 21 - Prob. 18TYRCh. 21 - Prob. 19TYRCh. 21 - Prob. 20TYRCh. 21 - Prob. 1BYMVCh. 21 - crino-Ch. 21 - extra-Ch. 21 - Prob. 4BYMVCh. 21 - Prob. 5BYMVCh. 21 - Prob. 6BYMVCh. 21 - Prob. 7BYMVCh. 21 - Prob. 8BYMVCh. 21 - Prob. 9BYMVCh. 21 - Prob. 10BYMVCh. 21 - Prob. 1WWTSCh. 21 - Prob. 2WWTSCh. 21 - Prob. 3WWTSCh. 21 - Prob. 4WWTSCh. 21 - Prob. 5WWTSCh. 21 - Prob. 6WWTSCh. 21 - Prob. 7WWTSCh. 21 - Prob. 8WWTSCh. 21 - Prob. 9WWTSCh. 21 - B cells that circulate freely in the bloodstream...Ch. 21 - Prob. 1TYCCh. 21 - Prob. 2TYCCh. 21 - A girl with a defective heart receives a new heart...Ch. 21 - A burn research center uses mice for studies of...Ch. 21 - Prob. 5TYC
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