Genetic Analysis: An Integrated Approach (2nd Edition)
2nd Edition
ISBN: 9780321948908
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 21, Problem 24P
The children of couples in which one partner has blood type O (genotype
a. What is the expected concordance rate for blood type of MZ twins in this study? Explain your answer.
b. What is the expected concordance rate for blood type of DZ twins in this study? Explain why this answer is different from the answer to part (a).
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Cystic fibrosis is an autosomal recessive disease characterized by two copies of a mutated CFTR gene. If one in 100 (hypothetical scenario, not reality) people in the United States have cystic fibrosis, calculate the p and q frequency for the normal allele (p) and the mutated allele (q). Based on those calculations, what percentage of individuals would be expected to be homozygous dominant?
Suppose there is an autosomal locus of 2 alleles, A1 and A2, with probabilities (frequencies) p1 and p2, and the genotype probabilities (frequencies) are P(A1A1) = p1*p1, P(A1A2) = 2*p1*p2, and P(A2A2) = p2*p2, respectively. Prove the Hardy-Weinberg Law, i.e., after one generation of random mating, the genotype probabilities (frequencies) in the offspring are also P(A1A1) = p1*p1, P(A1A2) = 2*p1*p2, and P(A2A2) = p2*p2. Hint: List all possible combinations of random mating. Then list the probabilities of the resulting genotype probabilities (frequencies) in the offspring. Combine the probabilities of random mating and resulting genotype probabilities (frequencies) in the offspring.
Chapter 21 Solutions
Genetic Analysis: An Integrated Approach (2nd Edition)
Ch. 21 - Which of the following traits would you expect to...Ch. 21 - 19.2 For the traits listed in the previous...Ch. 21 - Compare and contrast broad sense heritability and...Ch. 21 - 19.4 In a cross of two pure-breeding lines of...Ch. 21 - 19.5 Describe the difference between continuous...Ch. 21 - Prob. 6PCh. 21 - 19.7 Provide a definition and an example for each...Ch. 21 - 19.10 Three pairs of genes with two alleles each (...Ch. 21 - Prob. 9PCh. 21 - 19.12 Two inbred lines of sunflowers produce...
Ch. 21 - Prob. 11PCh. 21 - 19.14 In Nicotiana, two inbred strains produce...Ch. 21 - 19.15 Suppose the length of maize ears has narrow...Ch. 21 - In a line of cherry tomatoes, the average fruit...Ch. 21 - 19.17 Two purebreeding wheat strains, one...Ch. 21 - Prob. 16PCh. 21 - During a visit with your grandparents, they...Ch. 21 - 19.20 An association of racehorse owners is...Ch. 21 - Prob. 19PCh. 21 - Suppose a polygenic system for producing color in...Ch. 21 - New Zealand lamb breeders measure the following...Ch. 21 - Cattle breeders would like to improve the protein...Ch. 21 - In human gestational development, abnormalities of...Ch. 21 - The children of couples in which one partner has...Ch. 21 - Answer the following in regard to multifactorial...
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- Two parents, both with blood type A, have three children in a row with blood type O. a. Is this possible? If not, why not? If so, give the genotypes of the parents. i. What are the odds that, given the genotypes you list in 2.e., that the described scenario would actually happen? b. Could other children of this pair be born with blood type AB? Why not?arrow_forwardWhat is the first variable that can be calculated given these data, and what is the final variable we are requesting you to calculate? "In Finland, 256 people out of 10,000 are homozygous for the CCR5 allele mutation resulting in HIV resistance. Assuming the locus is in Hardy-Weinberg equilibrium, what is the expected genotype frequency of heterozygous carriers for the CCR5 mutation?"arrow_forwardConsider a locus with two alleles, A and a. If the frequency of AA is 0.30, what is the frequency of A under Hardy-Weinberg?arrow_forward
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- For each of the following characteristics, indicate whether it would be considered a discontinuous characteristic or a quantitative characteristic. Briefly justify your answer. a. Kernel color in a strain of wheat, in which two codominant alleles segregating at a single locus determine the color. Thus, there are three phenotypes present in this strain: white, light red, and medium red. b. Body weight in a family of Labrador retrievers. An autosomal recessive allele that causes dwarfism is present in this family. Two phenotypes are recognized: dwarf (less than 13 kg) and normal (greater than 23 kg). c. Presence or absence of leprosy. Susceptibility to leprosy is determined by multiple genes and numerous environmental factors. d. Number of toes in guinea pigs, which is influenced by genes at many loci. e. Number of fingers in humans. Extra (more than five) fingers are caused by the presence of an autosomal dominant allele.arrow_forwardGenotypes of leopard frogs from a population in central Kansas were determined for a locus (M) that encodes the enzyme malate dehydrogenase. The following numbers of genotypes were observed: Genotype Number M1M1 20 M1M2 45 M2M2 42 M1M3 4 M2M3 8 M3M3 6 Total 125 a. Calculate the genotypic and allelic frequencies for this population. b. What would the expected numbers of genotypes be if the population were in Hardy–Weinberg equilibrium?arrow_forwardAlbinism is a rare genetic condition, occurring in only one in every 17,000 to 22,000individuals in the world (Campbell et al. 2003; Gronskov et al. 2007). Conduct a library oronline research and answer these questions: A. What can you conclude about the allelic frequency of the a allele globally? B. Where do you think the a allele would be more commonly found, among theheterozygotes (Aa) or the homozygote recessives (aa)? Why do you say so? C. What happens to an individual who is albino (aa) or who has very low or lacksmelanin pigments in the hair, skin and eyes? D. Based on your answer in c, how would you explain the frequency of the a allele?arrow_forward
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