The pKa of uric acid is 5.61. The percent dissociation of uric acid in urine at a pH=6.0 is to be calculated. Why uric acid is acidic even though it does not have a COOH group is to be explained. Concept introduction: The Henderson-Hasselbalch equation is where, [A-] is the concentration of the dissociated uric acid and [HA] is the concentration of the undissociated uric acid. A compound will be acidic and donate a proton, if the conjugate base obtained is stabilized by resonance. To calculate: The percent dissociation of uric acid in urine at a pH=6.0 if its pKa is 5.61 and to explain why uric acid is acidic even though it does not have a COOH group.

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Protecting Groups and Carbonyls 6) The synthesis generates allethrolone that exhibits high insect toxicity but low mammalian toxicity. They are used in pet shampoo, human lice shampoo, and industrial sprays for insects and mosquitos. Propose detailed mechanistic steps to generate the allethrolone label the different types of reagents (Grignard, acid/base protonation, acid/base deprotonation, reduction, oxidation, witting, aldol condensation, Robinson annulation, etc.) III + VI HS HS H+ CH,CH,Li III I II IV CI + P(Ph)3 V ༼ Hint: no strong base added VI S VII IX HO VIII -MgBr HgCl2,HgO HO. isomerization aqeuous solution H,SO, ༽༽༤༽༽ X MeOH Hint: enhances selectivity for reaction at the S X ☑

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Chapter 20.SE, Problem 41AP

Interpretation Introduction

Interpretation:

The pKa of uric acid is 5.61. The percent dissociation of uric acid in urine at a pH=6.0 is to be calculated. Why uric acid is acidic even though it does not have a COOH group is to be explained.

Concept introduction:

The Henderson-Hasselbalch equation is

where, [A-] is the concentration of the dissociated uric acid and [HA] is the concentration of the undissociated uric acid.

A compound will be acidic and donate a proton, if the conjugate base obtained is stabilized by resonance.

To calculate:

The percent dissociation of uric acid in urine at a pH=6.0 if its pKa is 5.61 and to explain why uric acid is acidic even though it does not have a COOH group.

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