Genetics: From Genes to Genomes, 5th edition
Genetics: From Genes to Genomes, 5th edition
5th Edition
ISBN: 9780073525310
Author: Leland H. Hartwell, Michael L. Goldberg, Janice A. Fischer, Leroy Hood, Charles F. Aquadro
Publisher: McGraw-Hill Education
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Chapter 20, Problem 9P
Summary Introduction

a.

To determine:

The frequency of allele responsible for alkaptonuri.

Introduction:

Alkaptonuria is a type of disorder. It is a recessive autosomal genetic disorder. It is related to the darkening of urine. It has been found that 1 out of every 250,000 people suffer from this disorder.

Summary Introduction

b.

To determine:

The proportion of the population of U.S. that is carrier of alkaptonuria. The ratio of carriers of alkaptonuria to individuals affected by alkaptonuria.

Introduction:

The individuals that carry disease-causing genes are called carriers. The carriers are not the sufferer. The role of carriers is to pass the disease-causing genes to the next generation. Alkaptonuria is also a genetic disorder that is transmitted by the carriers to the next generation offsprings.

Summary Introduction

c.

To determine:

The chance that a child produced by the woman from her second marriage would have alkaptonuria.

Introduction:

The woman produces a child suffering from alkaptonuria from the first marriage. After some time, the woman gets remarried to another to another man. The woman can produce normal as well as the abnormal child with her second husband.

Summary Introduction

d.

To determine:

Whether the assumption of Hardy-Weinberg equilibrium can be used to estimate the allele frequencies and carrier frequencies of severe recessive autosomal disorders.

Introduction:

Geoffrey H. Hardy was a scientist who proposed the concept of Hardy-Weinberg equilibrium. This concept is used to associate the allele frequency with the genotype frequency. The proportion of gene copies that are of a common allele type in a population is termed as allele frequency.

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After you feel comfortable with your counting method and identifying cells in the various stages of mitosis, use the four images below of whitefish blastula to count the cells in each stage until you reach 100 total cells, recording your data below in Data Table 1. (You may not need to use all four images. Stop counting when you reach 100 total cells.) After totaling the cells in each stage, calculate the percent of cells in each stage. (Divide total of stage by overall total of 100 and then multiply by 100 to obtain percentage.)   Data Table 1Stage    Totals    PercentInterphase        Mitosis:        Prophase        Metaphase        Anaphase        Telophase        Cytokinesis        Totals    100    100% To find the length of time whitefish blastula cells spend in each stage, multiply the percent (recorded as a decimal, in other words take the percent number and divide by 100) by 24 hours. (Example: If percent is 20%, then Time in Hours = .2 * 24 = 4.8) Record your data in Data…

Chapter 20 Solutions

Genetics: From Genes to Genomes, 5th edition

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