Genetics: From Genes to Genomes, 5th edition
Genetics: From Genes to Genomes, 5th edition
5th Edition
ISBN: 9780073525310
Author: Leland H. Hartwell, Michael L. Goldberg, Janice A. Fischer, Leroy Hood, Charles F. Aquadro
Publisher: McGraw-Hill Education
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Chapter 20, Problem 23P

In Drosophila, the vestigial wings recessive allele, vg, causes the wings to be very small. A geneticist crossed some true-breeding wild-type males to some vestigial virgin females. The male and female F1 flies were wild type. He then allowed the F1 flies to mate with one another and found that 1/4 of the male and female F2 flies had vestigial wings. He dumped the vestigial F2 flies into a morgue and allowed the wild-type F2 flies to mate and produce an F3 generation.

a. Give the genotype and allele frequencies among the wild-type F2 flies.
b. What will be the frequencies of wild-type and vestigial flies in the F3?
c. Assuming the geneticist repeated the selection against the vestigial F3 flies (that is, he dumped them in a morgue and allowed the wild-type F3 flies to mate at random), what will be the frequency of the wild-type and mutant alleles in the F4 generation?
d. Now the geneticist lets all of the F4 flies mate at random (that is, both wild-type and vestigial flies mate). What will be the frequencies of wild-type and vestigial F5 flies?
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Genetics: From Genes to Genomes, 5th edition

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