Pearson eText Microbiology: An Introduction -- Instant Access (Pearson+)
13th Edition
ISBN: 9780135789377
Author: Gerard Tortora, Berdell Funke
Publisher: PEARSON+
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Textbook Question
Chapter 20, Problem 5R
List the advantages of using two chemotherapeutic agents simultaneously to treat a disease. What problem can be encountered using two drugs?
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Students have asked these similar questions
The type of antimicrobial drug that would be most likely to have toxic effects in
humans based on the premise of selective toxicity when treating microbial infection
would be a drug that
O 1) inhibits the synthesis of the cell wall
O 2) inhibits metabolic pathways
O 3) disrupts the cytoplasmic membrane
4) inhibits protein synthesis
5) All of the above have equal potential to be toxic
Name the five mechanisms of action we utilize to fight microorganisms and list one antibacterial drug for each.
When two antimicrobial drugs are used at the same time, antagonistic effects can occur. Which of the following is NOT a possible antagonistic effect of combining two antimicrobial drugs?
Increased elimination of one drug
Increased activity of both drugs
Increased toxicity
Decreased therapeutic levels
Decreased activity of both drugs
Chapter 20 Solutions
Pearson eText Microbiology: An Introduction -- Instant Access (Pearson+)
Ch. 20 - DRAW IT Show where the following antibiotics work:...Ch. 20 - List and explain five criteria used to identify an...Ch. 20 - What similar problems are encountered with...Ch. 20 - Define drug resistance. How is it produced? What...Ch. 20 - List the advantages of using two chemotherapeutic...Ch. 20 - Why does a cell die from the following...Ch. 20 - How does each of the following inhibit...Ch. 20 - The OH is missing from carbon 39 in ddI. How does...Ch. 20 - Compare the method of action of the following...Ch. 20 - NAME IT This microorganism is not susceptible to...
Ch. 20 - Which of the following pairs is mismatched? a....Ch. 20 - Prob. 2MCQCh. 20 - Prob. 3MCQCh. 20 - An antimicrobial agent should meet all of the...Ch. 20 - The most selective antimicrobial activity would be...Ch. 20 - Prob. 6MCQCh. 20 - Which of the following will not affect eukaryotic...Ch. 20 - Cell membrane damage causes death because a. the...Ch. 20 - A drug that intercalates into DNA has the...Ch. 20 - Chloramphenicol binds to the 50S portion of a...Ch. 20 - Prob. 1ACh. 20 - Why is idoxuridine effective if host cells also...Ch. 20 - Some bacteria become resistant to tetracycline...Ch. 20 - The following data were obtained from a...Ch. 20 - Prob. 5ACh. 20 - The following results were obtained from a broth...Ch. 20 - Vancomycin-resistant Enterococcus faecalis was...Ch. 20 - Prob. 2CAECh. 20 - Prob. 3CAE
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- What are the major causes of the ineffectiveness of anticancer therapies?arrow_forwardEnumerate the different sources of drug. Provide example for each source. Discuss the advantages and disadvantages of each source.arrow_forwardImportant characteristics of antimicrobial drugs include: a) readily delivered to the site of infection b) high toxicity against microbial cells c) do not cause serious side effects in humans d) remains active in body tissues and fluids e) all of the abovearrow_forward
- What is the definition of a crude drug? Describe the drug's origins.arrow_forwardPick a pathogen, suggest tests that should be performed on that pathogen to determine the specific drugs and give reasons why they would be appropriate. (Terminology to incorporate: narrow-spectrum, broad-spectrum, MIC, Kirby-Bauer, therapeutic index, selective toxicity, drug mechanism)arrow_forwardName and describe three mechanisms of acquired antimicrobial resistance tools that microbes may use to thwart drug action.arrow_forward
- According to USP Chapter <797>, allergenic extract preparation can be made in a doctor’s office facility by trained personnel only if the allergenic extract preparation: a)Is compounded under a laminar air flow hood Is compounded by a pharmacist b)Contains an antimicrobial preservative c)Is used immediately after preparation d)Is prepared only from plant origin materialarrow_forwardwhat is pharmacophore? what is the importance of pharmacophore in drug discovery?arrow_forwardAnswer in step by step with explanation. Don't use Ai and chatgpt. Answer in all options.arrow_forward
- Which of the following is true of selective toxicity? O 1) It refers to the process of determining the correct dose of a particular drug O 2) To be effective, an antimicrobial agent must be more toxic to the patient than 2) the pathogen O 3) It contributes to antibiotic resistance O 4) It refers to the body's ability to protect the brain and eye 5) It takes advantage of metabolic and structural differences between host and pathogenarrow_forwardWhere do chemotherapeutic agents come from?arrow_forwardBelow, you can see a picture of an antimicrobial drug. Regarding semi-synthetic antimicrobial drug development to try to avoid development of antibiotic resistance, use 1 sentence to address what is the significance/value of the presence of the various R-groups (e.g. R4, R5, R6, etc.)?arrow_forward
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