Pearson eText Microbiology: An Introduction -- Instant Access (Pearson+)
13th Edition
ISBN: 9780135789377
Author: Gerard Tortora, Berdell Funke
Publisher: PEARSON+
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Textbook Question
Chapter 20, Problem 5MCQ
The most selective antimicrobial activity would be exhibited by a drug that
a. inhibits cell wall synthesis.
b. inhibits protein synthesis.
c. injures the plasma membrane.
d. inhibits
e. all of the above
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Which of the following is not a factor that should be considered when selecting a antimicrobial drug?
A. The nature of the microbe causing the infection
B. The overall medical condition of the patient
C. The origin of the drug
D. The degree of susceptibility of the microbe to that drug
Which clinical situation would be appropriate for treatment with a narrow-spectrum antimicrobial drug?
Select one:
a.prophylaxis against infection after a surgical procedure
b.The treatment of strep throat caused by culture identified as Streptococcus pyogenes
c.None of the Above
d.the treatment of a polymicrobial mixed infection in the intestine
e.Empiric therapy (based on educated guesswork) of pneumonia while waiting for culture results
Which of the following statements concerning drug delivery system is INCORRECT?*
A.Drugs with good aqueous solubility are good for controlled release formulation.
B.The delay-released form is also called extended release form.
C.Absorption rate is higher in compressed tablets than that in capsules.
D.Drug core with polymer membrane coating belongs to diffusion sustained system.
E.Disintegration and dissolution can occur at the same time.
Chapter 20 Solutions
Pearson eText Microbiology: An Introduction -- Instant Access (Pearson+)
Ch. 20 - DRAW IT Show where the following antibiotics work:...Ch. 20 - List and explain five criteria used to identify an...Ch. 20 - What similar problems are encountered with...Ch. 20 - Define drug resistance. How is it produced? What...Ch. 20 - List the advantages of using two chemotherapeutic...Ch. 20 - Why does a cell die from the following...Ch. 20 - How does each of the following inhibit...Ch. 20 - The OH is missing from carbon 39 in ddI. How does...Ch. 20 - Compare the method of action of the following...Ch. 20 - NAME IT This microorganism is not susceptible to...
Ch. 20 - Which of the following pairs is mismatched? a....Ch. 20 - Prob. 2MCQCh. 20 - Prob. 3MCQCh. 20 - An antimicrobial agent should meet all of the...Ch. 20 - The most selective antimicrobial activity would be...Ch. 20 - Prob. 6MCQCh. 20 - Which of the following will not affect eukaryotic...Ch. 20 - Cell membrane damage causes death because a. the...Ch. 20 - A drug that intercalates into DNA has the...Ch. 20 - Chloramphenicol binds to the 50S portion of a...Ch. 20 - Prob. 1ACh. 20 - Why is idoxuridine effective if host cells also...Ch. 20 - Some bacteria become resistant to tetracycline...Ch. 20 - The following data were obtained from a...Ch. 20 - Prob. 5ACh. 20 - The following results were obtained from a broth...Ch. 20 - Vancomycin-resistant Enterococcus faecalis was...Ch. 20 - Prob. 2CAECh. 20 - Prob. 3CAE
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- Which of the following is NOT a property of an antimicrobial agent? a. Must have a known concentration over a period of time required to eliminate a pathogen b. all choices are correct c. must be selectively toxic d. Must have a favorable chemotherapeutic indexarrow_forwardWhether an antimicrobial is broad spectrum or narrow spectrum depends on its mode of action. For the following 2 hypothetical drugs, predict whether they are broad spectrum or narrow spectrum. Explain your reasoning: 4. a. Drug A interferes with peptidoglycan synthesis - b. Drug B interferes with 70S ribosome function- c. Drug C interferes with synthesis of a vitamin –arrow_forwardList and explain in your own words the 5 mechanisms of antimicrobial drug resistancearrow_forward
- Potential negative side-effects of antibiotic use include all of the following except… A. Allergic Reaction B. Development of a superinfection C. Toxicity to an organ or tissue in your body D. Body developing immunity to the antibioticarrow_forwardThere are many bacterial-antimicrobial resistance combinations. Which one of the following is of maior international concern? a. Sulfonamide resistance in Neisseria meningitides b. Penicillin G resistance in N. gonorrhoeae C. Ampicillin resistance in H. influenza d. Erythromycin resistance in S. pyogenes (group A streptococci) e. Vancomycin resistance in S. aureusarrow_forwardBroad-spectrum drugs target a wide variety of bacterial pathogens. Even when the broad-spectrum drug is capable of killing a target pathogen, it may not be the best treatment. Which statement best explains why a broad spectrum drug might be an undesirable treatment choice? Broad-spectrum antimicrobials are usually toxic to the host cells. Broad-spectrum antimicrobials only work if they are used shortly after the infection begins. Broad-spectrum antimicrobials may kill much of the normal microbiota. Broad-spectrum antimicrobials are not able to kill bacteria that are in their log phase of growth. Broad-spectrum antimicrobials may stimulate excess growth of the normal microbiota.arrow_forward
- The type of antimicrobial drug that would be most likely to have toxic effects in humans based on the premise of selective toxicity when treating microbial infection would be a drug that O 1) inhibits the synthesis of the cell wall O 2) inhibits metabolic pathways O 3) disrupts the cytoplasmic membrane 4) inhibits protein synthesis 5) All of the above have equal potential to be toxicarrow_forwardReviewing drug characteristics, choose an antimicrobial for each of the following situations (explain your choice): a. for an adult patient suffering from Mycoplasma pneumonia b. for a child with bacterial meningitis (drug must enter into cerebrospinal fl uid) c. for a patient who has chlamydiosis and an allergy to azithromycin d. for treating a child with Rocky Mountain spotted fever e. for PPNG drug-resistant gonorrheaarrow_forwardReviewing drug characteristics, choose an antimicrobial for each of the following situations (explain your choice): a. for an adult patient suffering from Mycoplasma pneumonia b. for a child with bacterial meningitis (drug must enter into cerebrospinal fl uid) c. for a patient who has chlamydiosis and an allergy to azithromycin d. for treating a child with Rocky Mountain spotted fever e. for PPNG drug-resistant gonorrheaarrow_forward
- . .arrow_forwardList 10 characteristics of an ideal antimicrobial drug.arrow_forwardBelow, you can see a picture of an antimicrobial drug. Regarding semi-synthetic antimicrobial drug development to try to avoid development of antibiotic resistance, use 1 sentence to address what is the significance/value of the presence of the various R-groups (e.g. R4, R5, R6, etc.)?arrow_forward
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