A mechanism for the conversion of dihydroxyacetone phosphate and glyceraldehyde-3-phosphate into fructose-1,6-bisphosphate should be proposed. Concept introduction: Aldolase catalyzes the aldol condensation between dihydroxyacetone phosphate and an aldehyde. Aldolase is highly specific for dihydroxyacetone but does not show any specificity towards aldehydes .

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Answer 1

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Definition Definition Organic compounds that have a carbonyl group, C=O, as their functional group. The carbonyl group in aldehydes is placed at the end of the molecular structure, which means the C=O is attached to one hydrogen atom and an alkyl group or a benzene ring. Just like all the other homologous series in organic chemistry, the naming of aldehydes uses the suffix “-al”. The general molecular formula is C n H 2n O.

Chapter 20, Problem 39P

Interpretation Introduction

Interpretation:

A mechanism for the conversion of dihydroxyacetone phosphate and glyceraldehyde-3-phosphate into fructose-1,6-bisphosphate should be proposed.

Concept introduction:

Aldolase catalyzes the aldol condensation between dihydroxyacetone phosphate and an aldehyde. Aldolase is highly specific for dihydroxyacetone but does not show any specificity towards aldehydes.

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The beta-lactamase hydrolyzes the lactam-ring in penicillin. Describe the mechanism of hydrolysis, insuring to include the involvement of S, D, & K in the reaction sequence. Please help

To map the active site of beta-lactamase, the enzyme was hydrolyzed with trypsin to yield a hexapeptide (P1) with the following amino acids. Glu, Lys, Leu, Phe, Met, and Ser. Treatment of P1 with phenyl isothiocyanate yielded a PTH derivative of phenylalanine and a peptide (P2). Treatment of P1 with cyanogenbromide gave an acidic tetrapeptide (P3) and a dipeptide (P4).Treatment of P2 with 1-fluoro-2,4-dinitrobenzene, followed by complete hydrolysis, yields N-2,4-dinitrophenyl-Glu. P1, P2, and P3 contain the active site serine. Why doesn't D in this hexapeptide not participate in the hydrolysis of the beta-lactam ring even though S, K, and D are involved in the catalyst?

To map the active site of -lactamase, the enzyme was hydrolyzed with trypsin to yield a hexapeptide (P1) with the following amino acids. Glu, Lys, Leu, Phe, Met, and Ser. Treatment of P1 with phenyl isothiocyanate yielded a PTH derivative of phenylalanine and a peptide (P2). Treatment of P1 with cyanogenbromide gave an acidic tetrapeptide (P3) and a dipeptide (P4).Treatment of P2 with 1-fluoro-2,4-dinitrobenzene, followed by complete hydrolysis, yields N-2,4-dinitrophenyl-Glu. P1, P2, and P3 contain the active site serine. Using the experimental results described above derive the primary sequence of the active site hexapeptide. Please help!

Answer 2

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Definition Definition Organic compounds that have a carbonyl group, C=O, as their functional group. The carbonyl group in aldehydes is placed at the end of the molecular structure, which means the C=O is attached to one hydrogen atom and an alkyl group or a benzene ring. Just like all the other homologous series in organic chemistry, the naming of aldehydes uses the suffix “-al”. The general molecular formula is C n H 2n O.

Chapter 20, Problem 39P

Interpretation Introduction

Interpretation:

A mechanism for the conversion of dihydroxyacetone phosphate and glyceraldehyde-3-phosphate into fructose-1,6-bisphosphate should be proposed.

Concept introduction:

Aldolase catalyzes the aldol condensation between dihydroxyacetone phosphate and an aldehyde. Aldolase is highly specific for dihydroxyacetone but does not show any specificity towards aldehydes.

Expert Solution & Answer

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Answer 3

Question

Definition Definition Organic compounds that have a carbonyl group, C=O, as their functional group. The carbonyl group in aldehydes is placed at the end of the molecular structure, which means the C=O is attached to one hydrogen atom and an alkyl group or a benzene ring. Just like all the other homologous series in organic chemistry, the naming of aldehydes uses the suffix “-al”. The general molecular formula is C n H 2n O.

Chapter 20, Problem 39P

Interpretation Introduction

Interpretation:

A mechanism for the conversion of dihydroxyacetone phosphate and glyceraldehyde-3-phosphate into fructose-1,6-bisphosphate should be proposed.

Concept introduction:

Aldolase catalyzes the aldol condensation between dihydroxyacetone phosphate and an aldehyde. Aldolase is highly specific for dihydroxyacetone but does not show any specificity towards aldehydes.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 4

Question

Definition Definition Organic compounds that have a carbonyl group, C=O, as their functional group. The carbonyl group in aldehydes is placed at the end of the molecular structure, which means the C=O is attached to one hydrogen atom and an alkyl group or a benzene ring. Just like all the other homologous series in organic chemistry, the naming of aldehydes uses the suffix “-al”. The general molecular formula is C n H 2n O.

Chapter 20, Problem 39P

Interpretation Introduction