Biology: The Unity and Diversity of Life
15th Edition
ISBN: 9780357093795
Author: STARR
Publisher: CENGAGE LEARNING (CUSTOM)
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Textbook Question
Chapter 20, Problem 2DAA
Bacteriophage-Inspired Antibiotics Although bacteriophages have been infecting bacteria for billions of years, no mechanism, has evolved in bacteria to prevent the viruses from lysing the cell walls of their hosts. Now, scientists are targeting the same bacterial wall components that bacteriophages do. The goal is to develop antibiotics that bacteria will be less likely to develop resistance to.
FIGURE 20.22 shows the results of a study to test Epimerox, a new bacteriophage-inspired antibiotic, against Bacillus anthracis, the bacterial species that causes the disease anthrax.
FIGURE 20.22 Effect of Epimerox on the survival of mice with anthrax. Mice were infected with the bacteria B. anthracis. One group of 15 then began receiving a drug-free buffer solution 3 hours later. Another 15 were treated with Epimerox beginning 3 hours after infection. A third group of 15was treated with Epimerox beginning 24 hours after infection.
What do these data indicate regarding the optimal time to begin Epimerox treatment?
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Glu-His-Trp-Ser-Gly-Leu-Arg-Pro-Gly
The pKa values for the peptide's side chains, terminal amino groups, and carboxyl groups are provided in the table.
Amino acid Amino pKa Carboxyl pKa Side-chain pKa
glutamate
9.60
2.34
histidine
9.17
1.82
4.25
6.00
tryptophan
9.39
2.38
serine
9.15
2.21
glycine
9.60
2.34
leucine
9.60
2.36
arginine
9.04
2.17
12.48
proline
10.96
1.99
Calculate the net charge of the molecule at pH 3.
net charge at pH 3:
Calculate the net charge of the molecule at pH 8.
net charge at pH 8:
Calculate the net charge of the molecule at pH 11.
net charge at pH 11:
Estimate the isoelectric point (pl) for this peptide.
pl:
Chapter 20 Solutions
Biology: The Unity and Diversity of Life
Ch. 20 - Bacteriophage-Inspired Antibiotics Although...Ch. 20 - Bacteriophage-Inspired Antibiotics Although...Ch. 20 - Bacteriophage-Inspired Antibiotics Although...Ch. 20 - The genome of ___ can be either RNA or DNA. a. a...Ch. 20 - The capsid of a virion consists of ___ . a. DNA b....Ch. 20 - Bacteriophages kill their host quickly by ______ ....Ch. 20 - The genetic material of HIV (a retrovirus) is...Ch. 20 - Prob. 5SQCh. 20 - Prob. 6SQCh. 20 - Prob. 7SQ
Ch. 20 - Bacteria that serve as decomposers are ___ . a....Ch. 20 - Prob. 9SQCh. 20 - Formation of a(n) ___ allows some soil bacteria to...Ch. 20 - _____ in the stomach of a cow release methane. a....Ch. 20 - A plasmid is a circle of ___ . a. RNA b. DNA c....Ch. 20 - Prob. 13SQCh. 20 - Prob. 14SQCh. 20 - Prob. 15SQCh. 20 - Prob. 1CTCh. 20 - Adenoviruses that cause colds do not have a lipid...Ch. 20 - The antibiotic penicillin acts by interfering with...Ch. 20 - Raw red alga of the genus Porphyra is part of a...
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