FUNDAMENTALS OF ANATOMY AND PHYSIOLOGY
11th Edition
ISBN: 2818440046582
Author: Martini
Publisher: PEARSON C
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Textbook Question
Chapter 20, Problem 24RQ
Differentiate between stroke volume and cardiac output. How is cardiac output calculated?
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 20 Solutions
FUNDAMENTALS OF ANATOMY AND PHYSIOLOGY
Ch. 20 - Prob. 1CPCh. 20 - Prob. 2CPCh. 20 - Why is the left ventricle more muscular than the...Ch. 20 - Define autorhythmicity.Ch. 20 - Which structure of the heart is known as the...Ch. 20 - Prob. 6CPCh. 20 - Why is it important for impulses from the atria to...Ch. 20 - Give the technical terms for heart contraction and...Ch. 20 - List the phases of the cardiac cycle.Ch. 20 - Is the heart always pumping blood when pressure in...
Ch. 20 - What could cause an increase in the size of the...Ch. 20 - Define cardiac output.Ch. 20 - Prob. 13CPCh. 20 - Prob. 14CPCh. 20 - Prob. 15CPCh. 20 - Prob. 16CPCh. 20 - Prob. 17CPCh. 20 - The great cardiac vein drains blood from the heart...Ch. 20 - The autonomic centers for cardiac function are...Ch. 20 - Prob. 3RQCh. 20 - The simple squamous epithelium covering the heart...Ch. 20 - The heart is surrounded by the (a) pleural cavity,...Ch. 20 - The cardiac skeleton of the heart has which two of...Ch. 20 - Cardiac output is equal to the (a) difference...Ch. 20 - Identify the superficial structures in the...Ch. 20 - Identify the structures in the following diagram...Ch. 20 - During diastole, a chamber of the heart (a)...Ch. 20 - During the cardiac cycle, the amount of blood...Ch. 20 - What role do the chordae tendineae and papillary...Ch. 20 - Describe the three distinct layers that make up...Ch. 20 - What are the valves in the heart, and what is the...Ch. 20 - Trace the normal pathway of an electrical impulse...Ch. 20 - What is the cardiac cycle? What phases and events...Ch. 20 - What three factors regulate stroke volume to...Ch. 20 - The cells of the conducting system differ from the...Ch. 20 - Which of the following is longer? (a) the...Ch. 20 - If the papillary muscles fail to contract, (a) the...Ch. 20 - Cardiac output cannot increase indefinitely...Ch. 20 - Describe the function of the SA node in the...Ch. 20 - What are the sources and significance of the four...Ch. 20 - Differentiate between stroke volume and cardiac...Ch. 20 - What factors influence cardiac output?Ch. 20 - What effect does sympathetic stimulation have on...Ch. 20 - Describe the effects of epinephrine,...Ch. 20 - Vern is suffering from cardiac arrhythmias and is...Ch. 20 - Harvey has a heart murmur in his left ventricle...Ch. 20 - The following measurements were made on two...Ch. 20 - Prob. 31RQCh. 20 - Prob. 1CCCh. 20 - Prob. 2CC
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