Human Biology: Concepts and Current Issues (8th Edition)
8th Edition
ISBN: 9780134042435
Author: Michael D. Johnson
Publisher: PEARSON
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Textbook Question
Chapter 20, Problem 12TY
A tiny amount of blood was recovered from a crime scene. What technique will enable comparison of this DNA to that of a potential suspect?
a. DNA fingerprinting
b. DNA cloning
c. DNA sequencing
d. gene therapy
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 20 Solutions
Human Biology: Concepts and Current Issues (8th Edition)
Ch. 20 - Prob. 1QCCh. 20 - GM foods are created for a variety of reasons,...Ch. 20 - Should foods that contain genetically modified...Ch. 20 - Explain how DNA is sequenced.Ch. 20 -
2. Describe the enzymes used in recombinant DNA...Ch. 20 - Prob. 3CRCh. 20 - Discuss the polymerase chain reaction technique,...Ch. 20 - Prob. 5CRCh. 20 - Prob. 6CRCh. 20 - Prob. 7CR
Ch. 20 - Prob. 8CRCh. 20 - Prob. 9CRCh. 20 -
10. List the diseases that gene therapy may be...Ch. 20 - Prob. 1TYCh. 20 - Prob. 2TYCh. 20 - Which of the following is used to separate...Ch. 20 - Genetically engineered human insulin, human growth...Ch. 20 - Prob. 5TYCh. 20 - All of the following statements about transgenic...Ch. 20 -
7. "Gene pharming” refers to:
a. using transgenic...Ch. 20 - Prob. 8TYCh. 20 - Prob. 9TYCh. 20 - Prob. 10TYCh. 20 - Which of the following is needed for sequencing...Ch. 20 - A tiny amount of blood was recovered from a crime...Ch. 20 - Which technique will allow amplification of the...Ch. 20 - A gene for a bacterial protein with insecticide...Ch. 20 - Prob. 15TYCh. 20 -
1. What do you think are the chances that someone...Ch. 20 - Imagine a future in which the respiratory effects...Ch. 20 - Prob. 3AWKCh. 20 - Prob. 4AWKCh. 20 - Prob. 5AWKCh. 20 - There is interest in producing vaccines in foods....Ch. 20 - Transgenic plants have the potential to improve...
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