Concept explainers
a.
To determine: The most likely mode of inheritance of the disease.
Introduction: Autosomal indicates the errors that happen on chromosome 1..22, preferably than on the 23rd sex-linked X chromosome. Also, the X-linked dominant genetic disorders concerning the 23rd X chromosome. Some models of autosomal dominant disorders are Huntington's disease and achondroplasia that is dwarfism.
b.
To determine: The genotype of each family member.
Introduction: The autosomal dominant inheritance model in an autosomal dominant disorder, the mutated gene is a dominant gene found on one of the nonsex chromosomes that are autosomes.
c.
To determine: Advice the three couples in the third generation about the likelihood of having an affected child as a family's doctor.
Introduction: Autosomal dominant is a feature or disorder that can be carried within families. In an autosomal dominant disorder, if one receives the abnormal gene from just one parent and can perceive the illness. Frequently, one of the parents also possesses the disease.
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INTRO TO GEN ANALYSIS W/ACHIEVE ACCESS
- The condition phenylketonuria is caused by a recessive allele. There are two carriers who have progeny.a. Give the gene notation. b. Give the expected genotypic and phenotypic ratios. c. What is the probability that their child will be heterozygous if they have a normal child?d. What is the probability of having two affected children and one normal child if they have three children?arrow_forwardDuchenne muscular dystrophy (DMD) is an example of an X-linked trait. This is a neuromuscular disease that causes muscles to slowly dehydrate, leading to paralysis. The disease allele is recessive (Xd) and the normal allele is dominant (XD). A female that is a carrier for DMD has kids with a normal male. Complete this cross on scratch paper and then answer the questions. A. What is the chance (%) that these two parents will have a kid with DMD? B. Their first child is a son. What is the chance (%) that he will have DMD? Hint: Look at only the male offspring when you answer this question.arrow_forwardThe pedigree chart provided below traces the occurrence of a disease through the generations of a family. Determine what type of inheritance pattern this disease has.arrow_forward
- Examine the pedigree and answer the following questions; shaded individuals show the trait; genotypes are all unknown. The individual marked with the question mark is of an unknown genotype but does have the trait. A. What mode of inheritance is the most likely for this trait, autosomal recessive or autosomal dominant? State your rationale for full credit. B. What is the genotype of the individual marked with the question mark? (Heterozygous, homozygous, or unknown)arrow_forwardExamine the pedigree and answer the following questions; shaded individuals show the trait; genotypes are all unknown. The individual marked with the question mark is of an unknown genotype but lacks the trait. A. What mode of inheritance is the most likely, autosomal recessive or autosomal dominant? State your rationale for full credit. B. What is the genotype of the individual designated with the question mark? (Heterozygous, homozygous, or unknown). C. What are the genotypes of the parents in generation I? (Heterozygous, homozygous, or unknown). D. What are the genotypes of the three children of generation IV? (Heterozygous, homozygous, or unknown).arrow_forwardA typical pedigree for a family that carries neurofibromatosis is shown below. Note that carriers are not indicated with half-colored shapes in this chart. Use the letter "N" to indicate the dominant neurofibromatosis allele, and the letter "n" for the normal allele. Use the below pedigree chart and your knowledge on how to interpret a pedigree chart to answer questions # 7-9. 1 Nn nn nn 3 nn 7. Is individual #1 most likely homozygous dominant or heterozygous? Explain how you can tell. 8. What is the genotype of individual #2? Explain how you can tell. 9. What is the genotype of individual #3? Explain how you can tell. 2)arrow_forward
- In this figure, the black circles and squares indicate a genetic disease. A. Based on the pedigree in the figure, does this gene appear to be inherited in a dominant or recessive manner? Explain your prediction. B. Use the letter a to indicate a disease allele and the letter A to indicate a normal allele. Predict the genotypes of the original parents. C. What percentage of the offspring of the original parents would you expect to have the disease? D. Predict the genotype of the partner of the diseased daughter in generation II. Justify your prediction.arrow_forwardThe following pedigree shows the inheritance of a rare genetic disorder. Determine the most likely mode of inheritance, and for exam practice (unmarked on the assignment) write a clear justification for your conclusion. Remember that some pedigrees don't provide sufficient data/information to discriminate between possibilities. If that is the case, select all the possible answers. I III Tb 2 3 1 1 3 autosomal dominant autosomal recessive Osex-linked dominant Osex-linked recessive O 2 Harrow_forwardDraw a pedigree chart for the following scenarios and answer the questions: 1. A woman's sister has cystic fibrosis, a disease caused by recessive genes. Neither of her parents has the disease. What chance is there that her mother is a carrier (heterozygous) for the trait? What chance is there that the woman herself is a carrier for the trait? 2. Huntington's disease is a degenerative disease of the nervous system which does not show up until age 40. It is caused by a dominant gene. John's father just began to show the symptoms. What is the chance that John will have the disease? 3. The pedigree below shows the blood types of some individuals. List all of the possible genotypes of the individuals and determine the blood group AND genotype of the missing blood groups. B ABarrow_forward
- Hemophilia is a disease caused by a gene found on the X chromosome. Therefore, it is referred to as a sex-linked disease. The recessive allele causes the disease. A man with hemophilia (xhy) marries a woman who is homozygous dominant (XHXH. A. Illustrate using a Punnett square the probability that their children will have the disease. B. Will any of their children have the disease? C. Predict the probabilities of their children having the disease.arrow_forwardThe following pedigree illustrates the inheritance of Duchenne Muscular Dystrophy, a condition characterized by progressive weakness and degeneration of skeletal muscles due to absence of dystrophin. 2.arrow_forwardO Huntington's Disease is a rare neurodegenerative disorder caused by a defective gene. A pedigree is shown below with a family that is affected. Describe the pattern of inheritance that Huntington's Disease is following. Justify your answer with reference to the diagram. Use proper notation (II-3, etc.) when referring to individuals. II 2 3 6 8 II 1 2 3 4 5 7.arrow_forward
- Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning