Introduction to Genetic Analysis
Introduction to Genetic Analysis
11th Edition
ISBN: 9781464109485
Author: Anthony J.F. Griffiths, Susan R. Wessler, Sean B. Carroll, John Doebley
Publisher: W. H. Freeman
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Chapter 2, Problem 57P

A.

Summary Introduction

To draw: The pedigree in the given case.

Introduction: Cystic fibrosis is a hereditary disease generated due to the mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene.

B.

Summary Introduction

To determine: The probability of the couple's first child to have cystic fibrosis

Introduction: Cystic fibrosis is the consequence of changes in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. About1,800 distinct mutations have been known that can induce cystic fibrosis. People acquiring two recessive CFTR alleles possess the disease.

C.

Summary Introduction

To determine: The probability of the second child being normal if the first child does have cystic fibrosis.

Introduction: Cystic fibrosis is an autosomal recessive disease, and this is the kind of condition one can acquire if both of the parents share a particular copy of a recessive gene. A recessive gene is one that can be concealed by a dominant gene.

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