Modified Mastering Microbiology wit
6th Edition
ISBN: 9780135174739
Author: BAUMAN
Publisher: PEARSON
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Chapter 2, Problem 3FIB
Summary Introduction
Introduction:
Cells must use energy to perform their vital functions. The energy of cells is composed of the breakdown of organic substrates. The cell requires ATP for transfer of the energy within the cell. In the metabolic processes, it converts to ADP or AMP. It is a form of energy that is stored by the cell in chemical form and can be used for various cellular processes.
ATP serves as an intermediate molecule in the fuel molecules, which contain a large amount of stored energy (potential energy) in their bonds. It is a ‘molecular unit of energy’ present in all forms of life.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 2 Solutions
Modified Mastering Microbiology wit
Ch. 2 - Electrons zip around the nucleus at about 5...Ch. 2 - Chlorine and potassium atoms form ionic bonds,...Ch. 2 - Why are decomposition reactions exothermic, that...Ch. 2 - Why does the neutralization of an acid by a base...Ch. 2 - Prob. 5TMWCh. 2 - Prob. 1CCSCh. 2 - Prob. 1MCCh. 2 - Prob. 2MCCh. 2 - Prob. 3MCCh. 2 - Prob. 4MC
Ch. 2 - Which of the following terms most correctly...Ch. 2 - Prob. 6MCCh. 2 - Prob. 7MCCh. 2 - Prob. 8MCCh. 2 - Prob. 9MCCh. 2 - Prob. 10MCCh. 2 - Prob. 1FIBCh. 2 - Prob. 2FIBCh. 2 - Prob. 3FIBCh. 2 - Prob. 4FIBCh. 2 - Prob. 5FIBCh. 2 - Prob. 6FIBCh. 2 - Reactions that release energy are called...Ch. 2 - Prob. 8FIBCh. 2 - Prob. 9FIBCh. 2 - Prob. 10FIBCh. 2 - Prob. 1VICh. 2 - Prob. 2VICh. 2 - Prob. 1SACh. 2 - Prob. 2SACh. 2 - Prob. 3SACh. 2 - Prob. 4SACh. 2 - Prob. 5SACh. 2 - Prob. 1CTCh. 2 - Prob. 2CTCh. 2 - Prob. 3CTCh. 2 - Prob. 4CTCh. 2 - Prob. 5CTCh. 2 - Prob. 6CTCh. 2 - Prob. 7CTCh. 2 - Prob. 8CTCh. 2 - Prob. 9CTCh. 2 - Prob. 10CTCh. 2 - Prob. 11CTCh. 2 - Prob. 12CTCh. 2 - Prob. 13CTCh. 2 - Prob. 14CTCh. 2 - A textbook states that only five nucleotide bases...Ch. 2 - Using the following terms, fill in the following...
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