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Biochemistry: Concepts and Connections (2nd Edition)
2nd Edition
ISBN: 9780134641621
Author: Dean R. Appling, Spencer J. Anthony-Cahill, Christopher K. Mathews
Publisher: PEARSON
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Question
Chapter 19, Problem 7P
Interpretation Introduction
Interpretation:
The text states that a side effect of 5-fluorouracil therapy is its incorporation into RNA. Show pathways by which 5-fluorouracil could be converted both to FdUMP and to an immediate RNA precursor.
Concept Introduction:
5-FU is converted into 5-fluorouridine triphosphate (FUTP). FUTP incorporates into RNA in place of uridylic acid. It alters aminoacylation of tRNA causing RNA miscoding and inhibits protein synthesis.
5-FU is
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Chapter 19 Solutions
Biochemistry: Concepts and Connections (2nd Edition)
Ch. 19 - Prob. 1PCh. 19 - Prob. 2PCh. 19 - Predict the effects of the following compounds on...Ch. 19 - Prob. 4PCh. 19 - Prob. 5PCh. 19 - Prob. 6PCh. 19 - Prob. 7PCh. 19 - A classic way to isolate thymidylate...Ch. 19 - Prob. 9PCh. 19 - Prob. 10P
Ch. 19 - Prob. 11PCh. 19 - Prob. 12PCh. 19 - Prob. 13PCh. 19 - Prob. 14PCh. 19 - Prob. 15PCh. 19 - Prob. 16PCh. 19 - Prob. 17PCh. 19 - Prob. 18PCh. 19 - Prob. 19PCh. 19 - Prob. 20PCh. 19 - Prob. 21PCh. 19 - Prob. 22PCh. 19 - Prob. 23PCh. 19 - Prob. 24PCh. 19 - Prob. 25PCh. 19 - Prob. 26PCh. 19 - Prob. 27P
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