To analyze:
The aim of GWAS (Genome wide association studies) is to locate chromosome regions containing the genes influencing the risk of disease, when applied to the study of the human genome. Unique articular genes can be identified in these regions; especially mutant alleles that intensify disease risk are to be sequenced. So far, the recognition of these alleles occasionally led to a new therapeutic strategy, but more frequently the identification of disease alleles is the only outcome.
a. From a physician’s perspective, describe the importance of identification of these alleles that increase the risk of a specific disease.
b. Explain the importance of identifying alleles that increase disease risk for a person who is currently free of the disease but what about the persons having pre-disposal of this disease that is running in the family.
c. Describe the personal or ethical issues occured from GWAS, might be of concern to physicians or to those who may carry an allele that increases the risk of disease.
Introduction:
GWAS is designed for the detection and location of the genes that influence the appearance of the trait by multiple genes. These multiple genes responsible for a particular trait are dispersed throughout the genome. Hence, the GWAS helps to locate the particular gene in the genome.
GWAS does not create any gene map of a chromosome rather it finds the association of traits and the groups of alleles to locate these influencing genes on different chromosomes.
In the GWAS, the term association refers to the trait co-occurs with group of alleles more often than expected.
The GWAS connects the presence of DNA marker having sequence variation with quantitative trait loci (QTL) affecting the particular
Want to see the full answer?
Check out a sample textbook solution
Chapter 19 Solutions
Genetic Analysis: An Integrated Approach (3rd Edition)
- Which of the following statements about hydration is true? Absence of thirst is a reliable indication that an individual is adequately hydrated. All of these statements are true. Although a popular way to monitor hydration status, weighing yourself before and after intensive physical activity is not a reliable method to monitor hydration. Urine that is the color of apple juice indicates dehydration. I don't know yetarrow_forwardThree of the many recessive mutations in Drosophila melanogaster that affect body color, wing shape, or bristle morphology are black (b) body versus grey in wild type, dumpy (dp), obliquely truncated wings versus long wings in the male, and hooked (hk) bristles versus not hooked in the wild type. From a cross of a dumpy female with a black and hooked male, all of the F1 were wild type for all three of the characters. The testcross of an F1 female with a dumpy, black, hooked male gave the following results: Trait Number of individuals Wild type 169 Black 19 Black, hooked 301 Dumpy, hooked 21 Hooked, dumpy, black 172 Dumpy, black 6 Dumpy 305 Hooked 8 Determine the order of the genes and the mapping distance between genes. Determine the coefficient of confidence for the portion of the chromosome involved in the cross. How much interference takes place in the cross?arrow_forwardWhat happens to a microbes membrane at colder temperature?arrow_forward
- Genes at loci f, m, and w are linked, but their order is unknown. The F1 heterozygotes from a cross of FFMMWW x ffmmww are test crossed. The most frequent phenotypes in the test cross progeny will be FMW and fmw regardless of what the gene order turns out to be. What classes of testcross progeny (phenotypes) would be least frequent if locus m is in the middle? What classes would be least frequent if locus f is in the middle? What classes would be least frequent if locus w is in the middle?arrow_forward1. In the following illustration of a phospholipid... (Chemistry Primer and Video 2-2, 2-3 and 2-5) a. Label which chains contain saturated fatty acids and non-saturated fatty acids. b. Label all the areas where the following bonds could form with other molecules which are not shown. i. Hydrogen bonds ii. Ionic Bonds iii. Hydrophobic Interactions 12-6 HICIH HICIH HICHH HICHH HICIH OHHHHHHHHHHHHHHHHH C-C-C-C-C-c-c-c-c-c-c-c-c-c-c-c-C-C-H HH H H H H H H H H H H H H H H H H H HO H-C-O H-C-O- O O-P-O-C-H H T HICIH HICIH HICIH HICIH HHHHHHH HICIH HICIH HICIH 0=C HIC -C-C-C-C-C-C-C-C-CC-C-C-C-C-C-C-C-C-H HHHHHHHHH IIIIIIII HHHHHHHH (e-osbiv)arrow_forwardAnswer this as a dental assistant studentarrow_forward
- buatkan judul skripsi tentang parasitologi yang sedang trendinharrow_forwardDental assistantarrow_forwardO Macmillan Learning Glu-His-Trp-Ser-Gly-Leu-Arg-Pro-Gly The pKa values for the peptide's side chains, terminal amino groups, and carboxyl groups are provided in the table. Amino acid Amino pKa Carboxyl pKa Side-chain pKa glutamate 9.60 2.34 histidine 9.17 1.82 4.25 6.00 tryptophan 9.39 2.38 serine 9.15 2.21 glycine 9.60 2.34 leucine 9.60 2.36 arginine 9.04 2.17 12.48 proline 10.96 1.99 Calculate the net charge of the molecule at pH 3. net charge at pH 3: Calculate the net charge of the molecule at pH 8. net charge at pH 8: Calculate the net charge of the molecule at pH 11. net charge at pH 11: Estimate the isoelectric point (pl) for this peptide. pl:arrow_forward
- Biology Questionarrow_forwardThis entire structure (Pinus pollen cone) using lifecycle terminology is called what?arrow_forwardThis entire structure using lifecycle terminology is called what? megastrobilus microstrobilus megasporophyll microsporophyll microsporangium megasporangium none of thesearrow_forward
Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning
Concepts of BiologyBiologyISBN:9781938168116Author:Samantha Fowler, Rebecca Roush, James WisePublisher:OpenStax College
Biology (MindTap Course List)BiologyISBN:9781337392938Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. BergPublisher:Cengage Learning
Case Studies In Health Information ManagementBiologyISBN:9781337676908Author:SCHNERINGPublisher:Cengage