ND STONY BROOK UNIVERSITY LOOSELEAF GENETICS: FROM GENES TO GENOMES
6th Edition
ISBN: 9781260406092
Author: HARTWELL, Leland, HOOD, Leroy, Goldberg, Michael
Publisher: Mcgraw-hill Education/stony Brook University
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Chapter 18, Problem 22P
Scientists now routinely use CRISPR/Cas9 to make defined deletions of a gene that can remove several kb of DNA from the genome. This method is possible even in cells defective in homologous recombination, as long as the cells can still perform nonhomologous end-joining (NHEJ).
| a. | How could researchers make such deletions? |
| b. | A GM animal that may be approved for human consumption by the time this book is published is a “supermuscly” pig made by inactivation of the myostatin gene. During normal development, Myostatin protein prevents the overgrowth of muscles. Given your answer to part (a), how could the supermuscly pig have been generated? |
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3.
In the tomato, red fruit (O+) is dominant over orange fruit (0), and yellow flowers (W+) are dominant over white
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333 red fruit, yellow flowers
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Name:
Date:
Investigation: Is a dog more closely related to a coyote or a wolf?
Gray Wolf
Species Name: Canis lupus
Color: Light gray to black
Size: 80-120 pounds, 2.5 feet tall
Appearance: broad snout, round ears, long tail
Coyote
Species Name: Canis latrans
Color: Light gray to brown
Size: 20-50 pounds, 1.5 feet tall
Appearance: narrow snout, pointed ears, long tail
Dog, Alaskan Malamute
Species Name: Canis lupus familiaris
Color: Gray and white or brown and white
Size: 70-80 pounds, 2 feet tall
Appearance: broad snout, round ears, long tail
1. Examine the images and descriptions above.
Underline any similarities between the dog and the wolf.
Place a star
next to any coyote traits that are similar to the dog.
2. Based on appearance alone, which do you think is the most closely related to a dog?
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Chapter 18 Solutions
ND STONY BROOK UNIVERSITY LOOSELEAF GENETICS: FROM GENES TO GENOMES
Ch. 18 - Match each of the terms in the left column to the...Ch. 18 - Mice are usually gray, but a mouse geneticist has...Ch. 18 - Sometimes, genes transferred into the mouse genome...Ch. 18 - In mice, a group of so-called Hox genes encode...Ch. 18 - The fly eyes shown in Fig. 18.7 are malformed...Ch. 18 - This problem concerns a technique called enhancer...Ch. 18 - Fish and other organisms that live in the Arctic...Ch. 18 - a. Describe two ways you could potentially make a...Ch. 18 - Figure 18.6 shows a picture of Glofish ,...Ch. 18 - Some people are concerned about the possible...
Ch. 18 - The goal of the Knockout Mouse Project is to...Ch. 18 - Prob. 12PCh. 18 - Prob. 13PCh. 18 - a. Which genome manipulation technique would you...Ch. 18 - a. Diagram a knockin construct that could have...Ch. 18 - Prob. 16PCh. 18 - Prob. 17PCh. 18 - The transcription factor Pax6 is required...Ch. 18 - Mouse models for human genetic diseases are...Ch. 18 - One way to determine where inside a cell a protein...Ch. 18 - In Problem 5 in Chapter 17, you saw that a SNP...Ch. 18 - Scientists now routinely use CRISPR/Cas9 to make...Ch. 18 - Geneticists are currently considering using...Ch. 18 - a. Figures 18.9 and 18.12 demonstrated methods to...Ch. 18 - Nonhomologous end-joining NHEJ of a double-strand...Ch. 18 - One problem that researchers sometimes encounter...Ch. 18 - Researchers at the University of California at San...Ch. 18 - Prob. 28PCh. 18 - F. Port and S. Bullock at the University of...Ch. 18 - On Fig 18.14, locate the PAM site and identify the...Ch. 18 - Prob. 31PCh. 18 - Prob. 32PCh. 18 - Recall that Leber congenital amaurosis LCA, a form...Ch. 18 - One potential strategy for gene therapy to correct...Ch. 18 - Recently, scientists have used a mouse model for...
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