Genetics: From Genes to Genomes
Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Chapter 18, Problem 17P
Summary Introduction

a.

To determine:

The ways by which pronuclear injection generated mice can be used to test the hypothesis of overexpression of myc in the B cells.

Introduction:

The tumour cells obtained from the patients of Burkitt lymphoma possess the myc gene that appears very close to the breakpoint of the reciprocal type of translocation.

Summary Introduction

b.

To determine:

The way by which transgenic mouse can be produced for the overexpression of myc and controlled expression of cre transgene.

Introduction:

Various scientists hypothesise that the overexpression of myc protein in the specialised B cells results in the formation of lymphoma in organisms.

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