Genetics: From Genes to Genomes
6th Edition
ISBN: 9781259700903
Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.
Publisher: McGraw-Hill Education
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Chapter 18, Problem 14P
| a. | Which genome manipulation technique would you use to create a mouse model for the human disease Leber congenital amaurosis (LCA), described at the very beginning of the chapter? Explain. |
| b. | Which procedure would you use to generate a mouse model for fragile X syndrome, a trinucleotide repeat disease caused by a mutant allele of the FMR-1 gene? (Review the Fast Forward Box in Chapter 7 entitled Trinucleotide Repeat Diseases: Huntington Disease and Fragile X Syndrome.) Explain. |
| c. | Which procedure would you use to create a mouse model for Huntington disease? |
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Please answer q3
Respond to the following in a minimum of 175 words:
How might CRISPR-Cas 9 be used in research or, eventually, therapeutically in patients?
What are some potential ethical issues associated with using this technology?
Do the advantages of using this technology outweigh the disadvantages (or vice versa)? Explain your position.
You are studying the effect of directional selection on body height in three
populations (graphs a, b, and c below).
(a) What is the selection differential? Show your calculation. (2 pts)
(b) Which population has the highest narrow sense heritability for height?
Explain your answer. (2 pts)
(c) If you examined the offspring in the next generation in each population,
which population would have the highest mean height? Why? (2 pts)
(a)
Midoffspring height (average height of offspring)
Short
Short
Short
Short
(c)
Short
(b)
Short
Tall
Short
Tall
Short
Short
Tall
Midparent height
(average height of
Mean of population = 65 inches
Mean of breading parents = 70 inches
Mean of population = 65 inches
Mean of breading parents = 70 inches
Mean of population = 65 inches
Mean of breading parents = 70 inches
Chapter 18 Solutions
Genetics: From Genes to Genomes
Ch. 18 - Match each of the terms in the left column to the...Ch. 18 - Mice are usually gray, but a mouse geneticist has...Ch. 18 - Sometimes, genes transferred into the mouse genome...Ch. 18 - In mice, a group of so-called Hox genes encode...Ch. 18 - The fly eyes shown in Fig. 18.7 are malformed...Ch. 18 - This problem concerns a technique called enhancer...Ch. 18 - Fish and other organisms that live in the Arctic...Ch. 18 - a. Describe two ways you could potentially make a...Ch. 18 - Figure 18.6 shows a picture of Glofish ,...Ch. 18 - Some people are concerned about the possible...
Ch. 18 - The goal of the Knockout Mouse Project is to...Ch. 18 - Prob. 12PCh. 18 - Prob. 13PCh. 18 - a. Which genome manipulation technique would you...Ch. 18 - a. Diagram a knockin construct that could have...Ch. 18 - Prob. 16PCh. 18 - Prob. 17PCh. 18 - The transcription factor Pax6 is required...Ch. 18 - Mouse models for human genetic diseases are...Ch. 18 - One way to determine where inside a cell a protein...Ch. 18 - In Problem 5 in Chapter 17, you saw that a SNP...Ch. 18 - Scientists now routinely use CRISPR/Cas9 to make...Ch. 18 - Geneticists are currently considering using...Ch. 18 - a. Figures 18.9 and 18.12 demonstrated methods to...Ch. 18 - Nonhomologous end-joining NHEJ of a double-strand...Ch. 18 - One problem that researchers sometimes encounter...Ch. 18 - Researchers at the University of California at San...Ch. 18 - Prob. 28PCh. 18 - F. Port and S. Bullock at the University of...Ch. 18 - On Fig 18.14, locate the PAM site and identify the...Ch. 18 - Prob. 31PCh. 18 - Prob. 32PCh. 18 - Recall that Leber congenital amaurosis LCA, a form...Ch. 18 - One potential strategy for gene therapy to correct...Ch. 18 - Recently, scientists have used a mouse model for...
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