Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN: 9781305251052
Author: Michael Cummings
Publisher: Cengage Learning
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Chapter 18, Problem 12QP
Animal Models: The Search for Behavior Genes
You are a researcher studying an autosomal dominant neurodegenerative disorder. You have cloned the gene underlying the disorder and have found that it encodes an enzyme that is overexpressed in the neurons of individuals who have the disorder. To better understand how this enzyme causes neurodegeneration in humans, you make a strain of transgenic Drosophila whose nerve cells overexpress the enzyme.
- a. How might you use these transgenic flies to try to gain insight into the disease or identify drugs that might be useful in the treatment of the disease?
- b. Can you think of any potential limitations of this approach?
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Chapter 18 Solutions
Human Heredity: Principles and Issues (MindTap Course List)
Ch. 18.2 - What role would twin and adoption studies play in...Ch. 18.2 - Prob. 2EGCh. 18 - Why do you think it has been so difficult to...Ch. 18 - If a test were available that could tell you...Ch. 18 - Prob. 1QPCh. 18 - Prob. 2QPCh. 18 - Prob. 3QPCh. 18 - List the steps involved in transmitting a nerve...Ch. 18 - Why do neurotransmitters have to be removed from...Ch. 18 - Prob. 6QP
Ch. 18 - Perfect pitch is the ability to identify a note...Ch. 18 - Prob. 8QPCh. 18 - Name three genes whose mutations lead to an...Ch. 18 - Prob. 10QPCh. 18 - Prob. 11QPCh. 18 - Animal Models: The Search for Behavior Genes You...Ch. 18 - Prob. 13QPCh. 18 - A pedigree analysis was performed on the family of...Ch. 18 - Prob. 15QPCh. 18 - A region on chromosome 6 has been linked to...Ch. 18 - Genetics and Social Behavior Of the following...Ch. 18 - Prob. 18QPCh. 18 - Prob. 19QP
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- Name three genes whose mutations lead to an altered behavioral phenotype. Briefly describe the normal function of the mutated gene as well as the altered phenotype.arrow_forwardEpigenetic Regulation of Learning and Memory: Accumulating evidence suggests that the epigenetic machinery might regulate the formation and stabilization of long-term memory. Answer the following questions: Review and summarize current literature, focusing on the involvement of epigenetic regulation in learning and memory.arrow_forwardSuggest and explain one way epigenetics may affect the age when symptoms of Huntington's disease start.arrow_forward
- Some people have said that epigenetics provides genes with a memory. Explain how epigenetics allows genes to remember.arrow_forwardHow can you envision using this new information? Discuss how things that we do to our bodies (smoking, recreational drugs, employment environments, stress levels, eating/drinking habits, etc.) can influence genetic expression in our future child(ren).arrow_forwardAnswer in step by step with explanation. Don't use Ai and chatgpt.arrow_forward
- answer all questions please.arrow_forwardDiscuss the similarities and differences of phenotypic variations that are caused by epigenetic gene regulation versus variation in gene sequences (epigenetics versus genetics).arrow_forwardIf you were to design an epigenetic experiment, how would you design one? Keep in mind a good experiment should have a strong, testable hypothesis, an overall goal, and expected results. What did agouti mice elucidate about how epigenetics are functioning? How does the structure of DNA change how genes are expressed? What are the different epigenetic modifications and what do they do?arrow_forward
- In the introduction to this chapter, we discussed the role of famine during early prenatal development and how, through epigenetic effects, it influenced the health of individuals as adults. One effect that has been observed in people who were conceived during the Dutch Hunger Winter is that they suffer more cognitive decline later in life. If these individuals were autopsied after death, what differences might you expect to see in the chromatin of their brain cells? What do the mouse studies of cognition and epigenetic effects suggest?arrow_forwardIf we knock out a gene, it can tell us something about how important that gene is or if other genes can compensate for its absence in a complex. To further establish the role of PSEN1 and PSEN2 in early onset Alzheimer's disease they are individually knocked out in mouse models. Knockout of PSEN1 leads to an embryonic lethal phenotype and dramatically reduced Aß levels. However knockout of PSEN2 gives no obvious phenotype and essentially normal AB levels. Question 16) Which of the following hypotheses does this observation support? [10 Marks] Under normal circumstances y-secretase complexes contain equal ratios of PSEN1 and PSEN2 b. The knockout of PSEN1 and PSEN2 didn't work O c. a. Under normal circumstances y-secretase complexes primarily contain PSEN2 rather than PSEN1 d. Under normal circumstances y-secretase complexes primarily contain PSEN1 rather than PSEN2 e. Under normal circumstances y-secretase complexes do not contain either PSEN1 or PSEN2arrow_forwardprovide one example from the Drosophila AP toolkit for "Toolkit genes can be classified according to the phenotypes caused by their mutation. Similar mutant phenotypes often reflect genes that function in a single developmental pathway. Distinct pathways exist for the generation of body axes, for example, and for the formation and identity of fields."arrow_forward
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