Biochemistry: Concepts and Connections (2nd Edition)
Biochemistry: Concepts and Connections (2nd Edition)
2nd Edition
ISBN: 9780134641621
Author: Dean R. Appling, Spencer J. Anthony-Cahill, Christopher K. Mathews
Publisher: PEARSON
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Chapter 18, Problem 12P
Interpretation Introduction

Interpretation:

Lysine degradation requires removal of two amino groups, removal of Biochemistry: Concepts and Connections (2nd Edition), Chapter 18, Problem 12P , additional homework tip  1amino group gives Biochemistry: Concepts and Connections (2nd Edition), Chapter 18, Problem 12P , additional homework tip  2aminoadipic semi aldehyde. This is then degraded to acetoacetate. To propose a pathway and its intermediates for lysine degradation.

Concept introduction:

Lysine is one of the essential amino acids but there is no lysine biosynthetic machinery available in humans, but there exists a degradation pathway. There are two distinct pathways for lysine degradation but the pathway involving saccharopine which converges at Biochemistry: Concepts and Connections (2nd Edition), Chapter 18, Problem 12P , additional homework tip  3aminoadipic semi aldehyde has been described here.

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