![EBK CHEMISTRY FOR CHANGING TIMES](https://www.bartleby.com/isbn_cover_images/8220100663482/8220100663482_largeCoverImage.jpg)
Interpretation:
Use the Merck Index or a similar reference work to look up the toxicities of cocaine, lidocaine, mepivacaine, and bupivacaine. It is always accurate to compare toxicities in different animals and extrapolate those animals toxicities to humans? Does the method of administration have an effect on the observed toxicity?
Concept introduction:
The different conversion methods of the drug’s toxicity which is dose related from animals to humans are being reviewed. Here every method is examined according to its limitation and utility. From animals to humans the linear extrapolation dependent on the equivalence of the body weight and shown to be not accurate unless specific conversion components of species are used. There are two approached are based on the Pharmacokinetic approach: -
- AUC i.e. direct use of plasma concentration
- PBPK models i.e. physiologically based pharmacokinetic.
![Check Mark](/static/check-mark.png)
Want to see the full answer?
Check out a sample textbook solution![Blurred answer](/static/blurred-answer.jpg)
Chapter 18 Solutions
EBK CHEMISTRY FOR CHANGING TIMES
- ChemistryChemistryISBN:9781305957404Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCostePublisher:Cengage LearningChemistryChemistryISBN:9781259911156Author:Raymond Chang Dr., Jason Overby ProfessorPublisher:McGraw-Hill EducationPrinciples of Instrumental AnalysisChemistryISBN:9781305577213Author:Douglas A. Skoog, F. James Holler, Stanley R. CrouchPublisher:Cengage Learning
- Organic ChemistryChemistryISBN:9780078021558Author:Janice Gorzynski Smith Dr.Publisher:McGraw-Hill EducationChemistry: Principles and ReactionsChemistryISBN:9781305079373Author:William L. Masterton, Cecile N. HurleyPublisher:Cengage LearningElementary Principles of Chemical Processes, Bind...ChemistryISBN:9781118431221Author:Richard M. Felder, Ronald W. Rousseau, Lisa G. BullardPublisher:WILEY
![Text book image](https://www.bartleby.com/isbn_cover_images/9781305957404/9781305957404_smallCoverImage.gif)
![Text book image](https://www.bartleby.com/isbn_cover_images/9781259911156/9781259911156_smallCoverImage.gif)
![Text book image](https://www.bartleby.com/isbn_cover_images/9781305577213/9781305577213_smallCoverImage.gif)
![Text book image](https://www.bartleby.com/isbn_cover_images/9780078021558/9780078021558_smallCoverImage.gif)
![Text book image](https://www.bartleby.com/isbn_cover_images/9781305079373/9781305079373_smallCoverImage.gif)
![Text book image](https://www.bartleby.com/isbn_cover_images/9781118431221/9781118431221_smallCoverImage.gif)